Unraveling pathophysiologic mechanisms contributing to symptoms in patients with post‐acute sequelae of COVID‐19 (PASC): A retrospective study

Patients with post‐acute sequelae of COVID‐19 (PASC) present with a decrease in physical fitness. The aim of this paper is to reveal the relations between the remaining symptoms, blood volume distribution, exercise tolerance, static and dynamic lung volumes, and overall functioning. Patients with PA...

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Bibliographic Details
Published in:Physiological reports 2023-06, Vol.11 (12), p.e15754-n/a
Main Authors: Dierckx, Wendel, De Backer, Wilfried, Ides, Kris, De Meyer, Yinka, Lauwers, Eline, Franck, Erik, De Backer, Jan
Format: Article
Language:English
Subjects:
Adult
Automation
Blood
Carbon monoxide
Chronic fatigue syndrome
Chronic illnesses
Complications
COVID-19
Disease
Dyspnea
Exercise
Exercise Test
Female
functional respiratory imaging
Hospitalization
Humans
Infections
Long COVID
Lung - diagnostic imaging
Lungs
Male
Middle Aged
Original
PASC
Patients
Physical fitness
Physiology
Post-Acute COVID-19 Syndrome - diagnosis
Post-Acute COVID-19 Syndrome - physiopathology
Post-Acute COVID-19 Syndrome - rehabilitation
Respiratory function
Respiratory Function Tests
Retrospective Studies
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Summary:Patients with post‐acute sequelae of COVID‐19 (PASC) present with a decrease in physical fitness. The aim of this paper is to reveal the relations between the remaining symptoms, blood volume distribution, exercise tolerance, static and dynamic lung volumes, and overall functioning. Patients with PASC were retrospectively studied. Pulmonary function tests (PFT), 6‐minute walk test (6MWT), and cardiopulmonary exercise test were performed. Chest CT was taken and quantified. Patients were divided into two groups: minor functional limitations (MFL) and severe functional limitations (SFL) based on the completed Post‐COVID‐19 Functional Status scale (PCFS). Twenty one patients (3 M; 18 FM), mean age 44 (IQR 21) were studied. Eighteen completed the PCFS (8 MFL; 10 SFL). VO2max was suboptimal in both groups (not significant). 6MWT was significantly higher in MFL‐group (p = 0.043). Subjects with SFL, had significant lower TLC (p = 0.029). The MFL‐group had more air trapping (p = 0.036). Throughout the sample, air trapping correlated significantly with residual volume (RV) in L (p 
ISSN:2051-817X
DOI:10.14814/phy2.15754