A comparison of the 33-item Hypomania Checklist with the 33-item Hypomania Checklist-external assessment for the detection of bipolar disorder in adolescents

Background Adolescents with bipolar disorder (BD) are often misdiagnosed as having major depressive disorder (MDD), which delays appropriate treatment and leads to adverse outcomes. The aim of this study was to compare the performance of the 33-item Hypomania Checklist (HCL-33) with the 33-item Hypo...

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Bibliographic Details
Published in:International Journal of Bipolar Disorders 2021-12, Vol.9 (1), p.41-41, Article 41
Main Authors: Chen, Xu, Bai, Wei, Zhao, Na, Sha, Sha, Cheung, Teris, Ungvari, Gabor S., Feng, Yuan, Xiang, Yu-Tao, Angst, Jules
Format: Article
Language:English
Subjects:
Adolescents
Behavioral Therapy
Bipolar disorder
Clinical Psychology
External assessment
HCL-33
Medicine
Medicine & Public Health
Neurology
Psychiatry
Psychopharmacology
Psychotherapy
Self-assessment
Short Communication
Teenagers
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Summary:Background Adolescents with bipolar disorder (BD) are often misdiagnosed as having major depressive disorder (MDD), which delays appropriate treatment and leads to adverse outcomes. The aim of this study was to compare the performance of the 33-item Hypomania Checklist (HCL-33) with the 33-item Hypomania Checklist- external assessment (HCL-33-EA) in adolescents with BD or MDD. Methods 147 adolescents with BD and 113 adolescents with MDD were consecutively recruited. The HCL-33 and HCL-33-EA were completed by patients and their carers, respectively. The sensitivity, positive predictive value (PPV), specificity, negative predictive value (NPV), and area under the curve (AUC) were calculated and compared between the two instruments, using cut-off values based on the Youden’s index. Results The total scores of the HCL-33 and HCL-33-EA were positively and significantly correlated ( rs  = 0.309, P  
ISSN:2194-7511
2194-7511
DOI:10.1186/s40345-021-00246-0