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A comparison of the 33-item Hypomania Checklist with the 33-item Hypomania Checklist-external assessment for the detection of bipolar disorder in adolescents
Background Adolescents with bipolar disorder (BD) are often misdiagnosed as having major depressive disorder (MDD), which delays appropriate treatment and leads to adverse outcomes. The aim of this study was to compare the performance of the 33-item Hypomania Checklist (HCL-33) with the 33-item Hypo...
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| Published in: | International Journal of Bipolar Disorders 2021-12, Vol.9 (1), p.41-41, Article 41 |
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| container_end_page | 41 |
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| container_start_page | 41 |
| container_title | International Journal of Bipolar Disorders |
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| creator | Chen, Xu Bai, Wei Zhao, Na Sha, Sha Cheung, Teris Ungvari, Gabor S. Feng, Yuan Xiang, Yu-Tao Angst, Jules |
| description | Background
Adolescents with bipolar disorder (BD) are often misdiagnosed as having major depressive disorder (MDD), which delays appropriate treatment and leads to adverse outcomes. The aim of this study was to compare the performance of the 33-item Hypomania Checklist (HCL-33) with the 33-item Hypomania Checklist- external assessment (HCL-33-EA) in adolescents with BD or MDD.
Methods
147 adolescents with BD and 113 adolescents with MDD were consecutively recruited. The HCL-33 and HCL-33-EA were completed by patients and their carers, respectively. The sensitivity, positive predictive value (PPV), specificity, negative predictive value (NPV), and area under the curve (AUC) were calculated and compared between the two instruments, using cut-off values based on the Youden’s index.
Results
The total scores of the HCL-33 and HCL-33-EA were positively and significantly correlated (
rs
= 0.309,
P
|
| doi_str_mv | 10.1186/s40345-021-00246-0 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_cb34f6f56cef4e4182193f03494e7717</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_cb34f6f56cef4e4182193f03494e7717</doaj_id><sourcerecordid>2611194519</sourcerecordid><originalsourceid>FETCH-LOGICAL-c592t-7049000e18ed1c197065b5ff08a927920cbc74fdfaabd7a5fb15a6923c59bfdb3</originalsourceid><addsrcrecordid>eNqFUk1v1DAUjBCIVkv_AAdkiQuXFDv-Si5I1QraSpW4wNly7OddL0kcbC_QH8N_xbsppeUAJ1t-M_PeG09VvST4nJBWvE0MU8Zr3JAa44aJGj-pThvSsVpyQp4-uJ9UZyntMMaEUEw7_rw6oaxrqCD4tPp5gUwYZx19ChMKDuUtIEprn2FEV7dzGPXkNVpvwXwZfMrou8_b_4Fq-JEhTnpAOiVIaYQpIxfikWchg8l-6db7OQw6IlvaRwsR-QlpGwZIpnDSi-qZ00OCs7tzVX3-8P7T-qq--Xh5vb64qQ3vmlxLzLqyH5AWLDGkk1jwnjuHW901smuw6Y1kzjqteys1dz3hWhQLCr13tqer6nrRtUHv1Bz9qOOtCtqr40OIG6Vj9mYAZXrKnHBcGHAMGGmLz9SVv-gYSElk0Xq3aM37fgR72CPq4ZHo48rkt2oTvqlWtIwLWgTe3AnE8HUPKavRFzuGQU8Q9kk1gjSYSilZgb7-C7oL-4PxRxQpCeBlulXVLCgTQ0oR3P0wBKtDmNQSJlXCpI5hUriQXj1c457yOzoFQBdAKqVpA_FP73_I_gIKe9b1</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2611194519</pqid></control><display><type>article</type><title>A comparison of the 33-item Hypomania Checklist with the 33-item Hypomania Checklist-external assessment for the detection of bipolar disorder in adolescents</title><source>PubMed (Medline)</source><source>Publicly Available Content Database</source><source>Social Science Premium Collection</source><source>Springer Nature - SpringerLink Journals - Fully Open Access</source><creator>Chen, Xu ; Bai, Wei ; Zhao, Na ; Sha, Sha ; Cheung, Teris ; Ungvari, Gabor S. ; Feng, Yuan ; Xiang, Yu-Tao ; Angst, Jules</creator><creatorcontrib>Chen, Xu ; Bai, Wei ; Zhao, Na ; Sha, Sha ; Cheung, Teris ; Ungvari, Gabor S. ; Feng, Yuan ; Xiang, Yu-Tao ; Angst, Jules</creatorcontrib><description>Background
Adolescents with bipolar disorder (BD) are often misdiagnosed as having major depressive disorder (MDD), which delays appropriate treatment and leads to adverse outcomes. The aim of this study was to compare the performance of the 33-item Hypomania Checklist (HCL-33) with the 33-item Hypomania Checklist- external assessment (HCL-33-EA) in adolescents with BD or MDD.
Methods
147 adolescents with BD and 113 adolescents with MDD were consecutively recruited. The HCL-33 and HCL-33-EA were completed by patients and their carers, respectively. The sensitivity, positive predictive value (PPV), specificity, negative predictive value (NPV), and area under the curve (AUC) were calculated and compared between the two instruments, using cut-off values based on the Youden’s index.
Results
The total scores of the HCL-33 and HCL-33-EA were positively and significantly correlated (
rs
= 0.309,
P
< 0.001). Compared to the HCL-33, the HCL-33-EA had higher sensitivity and NPV (HCL-33: sensitivity = 0.58, NPV = 0.53; HCL-33-EA: sensitivity = 0.81, NPV = 0.60), while the HCL-33 had higher specificity and PPV (HCL-33: specificity = 0.61, PPV = 0.66; HCL-33-EA: specificity = 0.37, PPV = 0.63).
Conclusion
Both the HCL-33 and HCL-33-EA seem to be useful for screening depressed adolescents for BD. The HCL-33-EA would be more appropriate for distinguishing BD from MDD in adolescents due to its high sensitivity in Chinese clinical settings.</description><identifier>ISSN: 2194-7511</identifier><identifier>EISSN: 2194-7511</identifier><identifier>DOI: 10.1186/s40345-021-00246-0</identifier><identifier>PMID: 34923610</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adolescents ; Behavioral Therapy ; Bipolar disorder ; Clinical Psychology ; External assessment ; HCL-33 ; Medicine ; Medicine & Public Health ; Neurology ; Psychiatry ; Psychopharmacology ; Psychotherapy ; Self-assessment ; Short Communication ; Teenagers</subject><ispartof>International Journal of Bipolar Disorders, 2021-12, Vol.9 (1), p.41-41, Article 41</ispartof><rights>The Author(s) 2021</rights><rights>2021. The Author(s).</rights><rights>The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c592t-7049000e18ed1c197065b5ff08a927920cbc74fdfaabd7a5fb15a6923c59bfdb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2611194519/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2611194519?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,21373,25731,27901,27902,33588,33589,36989,36990,43709,44566,53766,53768,73964,74869</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34923610$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Xu</creatorcontrib><creatorcontrib>Bai, Wei</creatorcontrib><creatorcontrib>Zhao, Na</creatorcontrib><creatorcontrib>Sha, Sha</creatorcontrib><creatorcontrib>Cheung, Teris</creatorcontrib><creatorcontrib>Ungvari, Gabor S.</creatorcontrib><creatorcontrib>Feng, Yuan</creatorcontrib><creatorcontrib>Xiang, Yu-Tao</creatorcontrib><creatorcontrib>Angst, Jules</creatorcontrib><title>A comparison of the 33-item Hypomania Checklist with the 33-item Hypomania Checklist-external assessment for the detection of bipolar disorder in adolescents</title><title>International Journal of Bipolar Disorders</title><addtitle>Int J Bipolar Disord</addtitle><addtitle>Int J Bipolar Disord</addtitle><description>Background
Adolescents with bipolar disorder (BD) are often misdiagnosed as having major depressive disorder (MDD), which delays appropriate treatment and leads to adverse outcomes. The aim of this study was to compare the performance of the 33-item Hypomania Checklist (HCL-33) with the 33-item Hypomania Checklist- external assessment (HCL-33-EA) in adolescents with BD or MDD.
Methods
147 adolescents with BD and 113 adolescents with MDD were consecutively recruited. The HCL-33 and HCL-33-EA were completed by patients and their carers, respectively. The sensitivity, positive predictive value (PPV), specificity, negative predictive value (NPV), and area under the curve (AUC) were calculated and compared between the two instruments, using cut-off values based on the Youden’s index.
Results
The total scores of the HCL-33 and HCL-33-EA were positively and significantly correlated (
rs
= 0.309,
P
< 0.001). Compared to the HCL-33, the HCL-33-EA had higher sensitivity and NPV (HCL-33: sensitivity = 0.58, NPV = 0.53; HCL-33-EA: sensitivity = 0.81, NPV = 0.60), while the HCL-33 had higher specificity and PPV (HCL-33: specificity = 0.61, PPV = 0.66; HCL-33-EA: specificity = 0.37, PPV = 0.63).
Conclusion
Both the HCL-33 and HCL-33-EA seem to be useful for screening depressed adolescents for BD. The HCL-33-EA would be more appropriate for distinguishing BD from MDD in adolescents due to its high sensitivity in Chinese clinical settings.</description><subject>Adolescents</subject><subject>Behavioral Therapy</subject><subject>Bipolar disorder</subject><subject>Clinical Psychology</subject><subject>External assessment</subject><subject>HCL-33</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neurology</subject><subject>Psychiatry</subject><subject>Psychopharmacology</subject><subject>Psychotherapy</subject><subject>Self-assessment</subject><subject>Short Communication</subject><subject>Teenagers</subject><issn>2194-7511</issn><issn>2194-7511</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>ALSLI</sourceid><sourceid>M2R</sourceid><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNqFUk1v1DAUjBCIVkv_AAdkiQuXFDv-Si5I1QraSpW4wNly7OddL0kcbC_QH8N_xbsppeUAJ1t-M_PeG09VvST4nJBWvE0MU8Zr3JAa44aJGj-pThvSsVpyQp4-uJ9UZyntMMaEUEw7_rw6oaxrqCD4tPp5gUwYZx19ChMKDuUtIEprn2FEV7dzGPXkNVpvwXwZfMrou8_b_4Fq-JEhTnpAOiVIaYQpIxfikWchg8l-6db7OQw6IlvaRwsR-QlpGwZIpnDSi-qZ00OCs7tzVX3-8P7T-qq--Xh5vb64qQ3vmlxLzLqyH5AWLDGkk1jwnjuHW901smuw6Y1kzjqteys1dz3hWhQLCr13tqer6nrRtUHv1Bz9qOOtCtqr40OIG6Vj9mYAZXrKnHBcGHAMGGmLz9SVv-gYSElk0Xq3aM37fgR72CPq4ZHo48rkt2oTvqlWtIwLWgTe3AnE8HUPKavRFzuGQU8Q9kk1gjSYSilZgb7-C7oL-4PxRxQpCeBlulXVLCgTQ0oR3P0wBKtDmNQSJlXCpI5hUriQXj1c457yOzoFQBdAKqVpA_FP73_I_gIKe9b1</recordid><startdate>20211218</startdate><enddate>20211218</enddate><creator>Chen, Xu</creator><creator>Bai, Wei</creator><creator>Zhao, Na</creator><creator>Sha, Sha</creator><creator>Cheung, Teris</creator><creator>Ungvari, Gabor S.</creator><creator>Feng, Yuan</creator><creator>Xiang, Yu-Tao</creator><creator>Angst, Jules</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><general>SpringerOpen</general><scope>C6C</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0-V</scope><scope>3V.</scope><scope>7XB</scope><scope>88J</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>M2O</scope><scope>M2R</scope><scope>MBDVC</scope><scope>PADUT</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20211218</creationdate><title>A comparison of the 33-item Hypomania Checklist with the 33-item Hypomania Checklist-external assessment for the detection of bipolar disorder in adolescents</title><author>Chen, Xu ; Bai, Wei ; Zhao, Na ; Sha, Sha ; Cheung, Teris ; Ungvari, Gabor S. ; Feng, Yuan ; Xiang, Yu-Tao ; Angst, Jules</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c592t-7049000e18ed1c197065b5ff08a927920cbc74fdfaabd7a5fb15a6923c59bfdb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adolescents</topic><topic>Behavioral Therapy</topic><topic>Bipolar disorder</topic><topic>Clinical Psychology</topic><topic>External assessment</topic><topic>HCL-33</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neurology</topic><topic>Psychiatry</topic><topic>Psychopharmacology</topic><topic>Psychotherapy</topic><topic>Self-assessment</topic><topic>Short Communication</topic><topic>Teenagers</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Xu</creatorcontrib><creatorcontrib>Bai, Wei</creatorcontrib><creatorcontrib>Zhao, Na</creatorcontrib><creatorcontrib>Sha, Sha</creatorcontrib><creatorcontrib>Cheung, Teris</creatorcontrib><creatorcontrib>Ungvari, Gabor S.</creatorcontrib><creatorcontrib>Feng, Yuan</creatorcontrib><creatorcontrib>Xiang, Yu-Tao</creatorcontrib><creatorcontrib>Angst, Jules</creatorcontrib><collection>Springer Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Social Sciences Premium Collection【Remote access available】</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Social Science Database (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>Social Science Premium Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Research Library</collection><collection>Social Science Database</collection><collection>Research Library (Corporate)</collection><collection>Research Library China</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Directory of Open Access Journals</collection><jtitle>International Journal of Bipolar Disorders</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Xu</au><au>Bai, Wei</au><au>Zhao, Na</au><au>Sha, Sha</au><au>Cheung, Teris</au><au>Ungvari, Gabor S.</au><au>Feng, Yuan</au><au>Xiang, Yu-Tao</au><au>Angst, Jules</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A comparison of the 33-item Hypomania Checklist with the 33-item Hypomania Checklist-external assessment for the detection of bipolar disorder in adolescents</atitle><jtitle>International Journal of Bipolar Disorders</jtitle><stitle>Int J Bipolar Disord</stitle><addtitle>Int J Bipolar Disord</addtitle><date>2021-12-18</date><risdate>2021</risdate><volume>9</volume><issue>1</issue><spage>41</spage><epage>41</epage><pages>41-41</pages><artnum>41</artnum><issn>2194-7511</issn><eissn>2194-7511</eissn><abstract>Background
Adolescents with bipolar disorder (BD) are often misdiagnosed as having major depressive disorder (MDD), which delays appropriate treatment and leads to adverse outcomes. The aim of this study was to compare the performance of the 33-item Hypomania Checklist (HCL-33) with the 33-item Hypomania Checklist- external assessment (HCL-33-EA) in adolescents with BD or MDD.
Methods
147 adolescents with BD and 113 adolescents with MDD were consecutively recruited. The HCL-33 and HCL-33-EA were completed by patients and their carers, respectively. The sensitivity, positive predictive value (PPV), specificity, negative predictive value (NPV), and area under the curve (AUC) were calculated and compared between the two instruments, using cut-off values based on the Youden’s index.
Results
The total scores of the HCL-33 and HCL-33-EA were positively and significantly correlated (
rs
= 0.309,
P
< 0.001). Compared to the HCL-33, the HCL-33-EA had higher sensitivity and NPV (HCL-33: sensitivity = 0.58, NPV = 0.53; HCL-33-EA: sensitivity = 0.81, NPV = 0.60), while the HCL-33 had higher specificity and PPV (HCL-33: specificity = 0.61, PPV = 0.66; HCL-33-EA: specificity = 0.37, PPV = 0.63).
Conclusion
Both the HCL-33 and HCL-33-EA seem to be useful for screening depressed adolescents for BD. The HCL-33-EA would be more appropriate for distinguishing BD from MDD in adolescents due to its high sensitivity in Chinese clinical settings.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>34923610</pmid><doi>10.1186/s40345-021-00246-0</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescents Behavioral Therapy Bipolar disorder Clinical Psychology External assessment HCL-33 Medicine Medicine & Public Health Neurology Psychiatry Psychopharmacology Psychotherapy Self-assessment Short Communication Teenagers |
| title | A comparison of the 33-item Hypomania Checklist with the 33-item Hypomania Checklist-external assessment for the detection of bipolar disorder in adolescents |
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