The Potential Role of Urinary Microbiome in Benign Prostate Hyperplasia/Lower Urinary Tract Symptoms

Historically, urine in the urinary tract was considered “sterile” based primarily on culture-dependent methods of bacterial detection. Rapidly developing sequencing methods and analytical techniques have detected bacterial deoxyribonucleic acid and live bacteria in urine, improving our ability to un...

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Bibliographic Details
Published in:Diagnostics (Basel) 2022-08, Vol.12 (8), p.1862
Main Authors: Yu, Seong Hyeon, Jung, Seung Il
Format: Article
Language:English
Subjects:
Bacteria
benign prostate hyperplasia
Bladder
Catheters
Deoxyribonucleic acid
Disease
DNA
Females
Health aspects
Hyperplasia
Inflammation
Intubation
lower urinary tract symptoms
Methods
Microbiota
Microbiota (Symbiotic organisms)
Microorganisms
Prostate
Review
urinary microbiome
Urine
Urogenital system
Vagina
Womens health
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Summary:Historically, urine in the urinary tract was considered “sterile” based primarily on culture-dependent methods of bacterial detection. Rapidly developing sequencing methods and analytical techniques have detected bacterial deoxyribonucleic acid and live bacteria in urine, improving our ability to understand the urinary tract microbiome. Recently, many studies have revealed evidence of a microbial presence in human urine in the absence of clinical infections. In women, fascinating evidence associates urinary tract microbiota with lower urinary tract symptoms (LUTS). However, the association between urinary tract microbiota and men with LUTS, particularly those with benign prostate hyperplasia (BPH), has not been established. In addition, the identification of the proinflammatory cytokines and pathogens responsible for the clinical progression of BPH is still underway. This review article aimed to address microbiome-related evidence for BPH. Further studies are required for a comprehensive understanding of the relationship between the urogenital microbiome and BPH pathogenesis to facilitate the development of preventive and therapeutic approaches for male LUTS.
ISSN:2075-4418
2075-4418
DOI:10.3390/diagnostics12081862