The Dual Roles of Activating Transcription Factor 3 (ATF3) in Inflammation, Apoptosis, Ferroptosis, and Pathogen Infection Responses

Transcription factors are pivotal regulators in the cellular life process. Activating transcription factor 3 (ATF3), a member of the ATF/CREB (cAMP response element-binding protein) family, plays a crucial role as cells respond to various stresses and damage. As a transcription factor, ATF3 signific...

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Bibliographic Details
Published in:International journal of molecular sciences 2024-01, Vol.25 (2), p.824
Main Authors: Liu, Shuang, Li, Zhangcheng, Lan, Shimei, Hao, Huafang, Baz, Ahmed Adel, Yan, Xinmin, Gao, Pengcheng, Chen, Shengli, Chu, Yuefeng
Format: Article
Language:English
Subjects:
Activating Transcription Factor 3 - genetics
Apoptosis
ATF3
Binding sites
Cell death
Cellular signal transduction
Cyclic adenylic acid
Cyclic AMP Response Element-Binding Protein
Cytokines
Development and progression
DNA binding proteins
DNA damage
Endoplasmic reticulum
Ferroptosis
Genes
Genetic engineering
Health aspects
Humans
Immune response
Inflammation
inflammatory
Kinases
microorganism
Oxidative stress
Pathogens
Physiology
Protein binding
Streptococcus infections
Transcription factors
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Summary:Transcription factors are pivotal regulators in the cellular life process. Activating transcription factor 3 (ATF3), a member of the ATF/CREB (cAMP response element-binding protein) family, plays a crucial role as cells respond to various stresses and damage. As a transcription factor, ATF3 significantly influences signal transduction regulation, orchestrating a variety of signaling pathways, including apoptosis, ferroptosis, and cellular differentiation. In addition, ATF3 serves as an essential link between inflammation, oxidative stress, and immune responses. This review summarizes the recent advances in research on ATF3 activation and its role in regulating inflammatory responses, cell apoptosis, and ferroptosis while exploring the dual functions of ATF3 in these processes. Additionally, this article discusses the role of ATF3 in diseases related to pathogenic microbial infections. Our review may be helpful to better understand the role of ATF3 in cellular responses and disease progression, thus promoting advancements in clinical treatments for inflammation and oxidative stress-related diseases.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms25020824