Rodent Models of Audiogenic Epilepsy: Genetic Aspects, Advantages, Current Problems and Perspectives

Animal models of epilepsy are of great importance in epileptology. They are used to study the mechanisms of epileptogenesis, and search for new genes and regulatory pathways involved in the development of epilepsy as well as screening new antiepileptic drugs. Today, many methods of modeling epilepsy...

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Bibliographic Details
Published in:Biomedicines 2022-11, Vol.10 (11), p.2934
Main Authors: Garbuz, David G, Davletshin, Artem A, Litvinova, Svetlana A, Fedotova, Irina B, Surina, Natalya M, Poletaeva, Inga I
Format: Article
Language:English
Subjects:
Animal models
Antiepileptic agents
audiogenic epilepsy
Brain
Classification
Consciousness
Convulsions & seizures
Disease
Drug development
Drug screening
Electroconvulsive therapy
Encephalitis
Epilepsy
epilepsy-associated genes
Etiology
Fainting
GASH/Sal hamster strain
Genetic aspects
genetic epilepsy models
Kinases
KM rats
Metabolism
Morphology
Mutation
Pathogenesis
Review
Seizures
Stroke
Trauma
WAR rats
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Summary:Animal models of epilepsy are of great importance in epileptology. They are used to study the mechanisms of epileptogenesis, and search for new genes and regulatory pathways involved in the development of epilepsy as well as screening new antiepileptic drugs. Today, many methods of modeling epilepsy in animals are used, including electroconvulsive, pharmacological in intact animals, and genetic, with the predisposition for spontaneous or refractory epileptic seizures. Due to the simplicity of manipulation and universality, genetic models of audiogenic epilepsy in rodents stand out among this diversity. We tried to combine data on the genetics of audiogenic epilepsy in rodents, the relevance of various models of audiogenic epilepsy to certain epileptic syndromes in humans, and the advantages of using of rodent strains predisposed to audiogenic epilepsy in current epileptology.
ISSN:2227-9059
2227-9059
DOI:10.3390/biomedicines10112934