Connexin and Pannexin Large-Pore Channels in Microcirculation and Neurovascular Coupling Function

Microcirculation homeostasis depends on several channels permeable to ions and/or small molecules that facilitate the regulation of the vasomotor tone, hyperpermeability, the blood–brain barrier, and the neurovascular coupling function. Connexin (Cxs) and Pannexin (Panxs) large-pore channel proteins...

Full description

Saved in:
Bibliographic Details
Published in:International journal of molecular sciences 2022-07, Vol.23 (13), p.7303
Main Authors: Burboa, Pía C., Puebla, Mariela, Gaete, Pablo S., Durán, Walter N., Lillo, Mauricio A.
Format: Article
Language:English
Subjects:
Arterioles
Blood vessels
Blood-brain barrier
Calcium ions
Capillaries
Channels
Communication
D-Serine
Endothelium
gap junction
hemichannels
Homeostasis
Hypotension
Metabolites
microcirculation
Molecular weight
Nitric oxide
Physiology
Prostaglandins
Proteins
Review
Smooth muscle
Veins & arteries
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Microcirculation homeostasis depends on several channels permeable to ions and/or small molecules that facilitate the regulation of the vasomotor tone, hyperpermeability, the blood–brain barrier, and the neurovascular coupling function. Connexin (Cxs) and Pannexin (Panxs) large-pore channel proteins are implicated in several aspects of vascular physiology. The permeation of ions (i.e., Ca2+) and key metabolites (ATP, prostaglandins, D-serine, etc.) through Cxs (i.e., gap junction channels or hemichannels) and Panxs proteins plays a vital role in intercellular communication and maintaining vascular homeostasis. Therefore, dysregulation or genetic pathologies associated with these channels promote deleterious tissue consequences. This review provides an overview of current knowledge concerning the physiological role of these large-pore molecule channels in microcirculation (arterioles, capillaries, venules) and in the neurovascular coupling function.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms23137303