Contiguous follicular lymphoma and follicular lymphoma in situ harboring N-glycosylated sites

Follicular lymphoma in situ (FLIS) is composed of a clonal B-cell population harboring the typical t(14;18) hallmark of follicular lymphoma (FL), forming unconventional BCL2 Bright CD10 + cell foci in an otherwise normal reactive lymph node (LN). The diagnosis of FLIS is made on the fortuitous disco...

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Bibliographic Details
Published in:Haematologica (Roma) 2015-04, Vol.100 (4), p.e155-e157
Main Authors: Mamessier, Emilie, Drevet, Charlotte, Broussais-Guillaumot, Florence, Mollichella, Marie-Laure, Garciaz, Sylvain, Roulland, Sandrine, Benchetrit, Maxime, Nadel, Bertrand, Xerri, Luc
Format: Article
Language:English
Subjects:
Adult
Cancer
Cellular Biology
Glycosylation
Humans
Immunoglobulin Heavy Chains - chemistry
Immunoglobulin Heavy Chains - genetics
Immunoglobulin Variable Region - chemistry
Immunoglobulin Variable Region - genetics
In Situ Hybridization, Fluorescence
Life Sciences
Lymph Nodes - metabolism
Lymph Nodes - pathology
Lymphoma, Follicular - genetics
Lymphoma, Follicular - metabolism
Lymphoma, Follicular - pathology
Male
Neoplasm Staging
Nucleotide Motifs
Online Only
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Summary:Follicular lymphoma in situ (FLIS) is composed of a clonal B-cell population harboring the typical t(14;18) hallmark of follicular lymphoma (FL), forming unconventional BCL2 Bright CD10 + cell foci in an otherwise normal reactive lymph node (LN). The diagnosis of FLIS is made on the fortuitous discovery of unconventional BCL2 Bright CD10 + cell foci. 1 Several studies recently demonstrated that FLIS are already advanced precursors in follicular lymphomagene-sis, but not necessarily committed to malignant transformation. 2,3 However, the relationship between FLIS and FL still remains unclear, as only a minority (
ISSN:0390-6078
1592-8721
DOI:10.3324/haematol.2014.115782