The Many Faces of Oral-Facial-Digital Syndrome

The oral-facial-digital (OFD) syndrome is a heterogeneous group of abnormalities that share anomalies of the oral cavity, face and digits of hands and feet. On the basis of other anomalies of brain, kidneys, limbs, eyes and other organs, at least 13 subgroups have been described. We here describe fo...

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Bibliographic Details
Published in:Balkan journal of medical genetics 2012-01, Vol.15 (1), p.37-44
Main Authors: Sukarova-Angelovska, E, Angelkova, N, Palcevska-Kocevska, S, Kocova, M
Format: Article
Language:English
Subjects:
Ciliopathy
Genetic and clinical heterogeneity
Oral cleft
Oral-facial-digital (OFD) syndrome
Original
Polydactyly
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Summary:The oral-facial-digital (OFD) syndrome is a heterogeneous group of abnormalities that share anomalies of the oral cavity, face and digits of hands and feet. On the basis of other anomalies of brain, kidneys, limbs, eyes and other organs, at least 13 subgroups have been described. We here describe four unrelated patients with this syndrome, who have the typical facial, oral and digital anomalies and also anomalies of other organs and systems. Facial features, digital malformations, as well as the existence of additional malformations all of which can be classified into different subgroups. The report points out the difficulty in delineation of the subtypes of OFD syndrome because of the overlapping features between OFD subgroups.
ISSN:1311-0160
2199-5761
DOI:10.2478/v10034-012-0006-y