Effect of mitochondrial coenzyme‐Q10 precursor solanesol in gentamicin‐induced experimental nephrotoxicity: Evidence from restoration of ETC‐complexes and histopathological alterations

• Published in: Pharmacology research & perspectives 2024-10, Vol.12 (5), p.e70022-n/a
• Main Authors: Sangwan, Minakshi, Chaudhary, Hema, Mehan, Sidharth, Khan, Zuber, Bahauddin, Ammar A., Alrehaili, Bandar D., Elbadawy, Hossein M., Almikhlafi, Mohannad A., Narula, Acharan S., Kalfin, Reni, Wanas, Hanna
• Format: Article
• Language: English
• Subjects: Acids; Adenosine; Animals; Anti-Bacterial Agents - toxicity; Antioxidants - pharmacology; Antioxidants - therapeutic use; Blood Urea Nitrogen; Cancer; Cooling; CoQ; Creatinine; Creatinine - blood; Drug dosages; gentamicin; Gentamicins - toxicity; Glutathione - metabolism; Gram-positive bacteria; Kidney - drug effects; Kidney - metabolism; Kidney - pathology; Kidney diseases; Kidney Diseases - chemically induced; Kidney Diseases - metabolism; Kidney Diseases - pathology; Kidney Diseases - prevention & control; Male; methylprednisolone; Migraine; Mitochondria - drug effects; Mitochondria - metabolism; mitochondrial dysfunction; nephroprotection; nephrotoxicity; Nitrogen; Original; Oxidative stress; Oxidative Stress - drug effects; Rats; Rats, Wistar; Reagents; Sodium; solanesol; Terpenes - pharmacology; Terpenes - therapeutic use; Thiobarbituric Acid Reactive Substances - metabolism; Tumor Necrosis Factor-alpha - blood; Tumor Necrosis Factor-alpha - metabolism; Tumor necrosis factor-TNF; Ubiquinone - analogs & derivatives; Ubiquinone - pharmacology; Ubiquinone - therapeutic use
• ISSN: 2052-1707; 2052-1707
• DOI: 10.1002/prp2.70022

Nephrotoxicity occurs when the body is exposed to certain drugs or toxins. When kidney damage occurs, the kidney fails to eliminate excess urine and waste. Solanesol (C45H74O) is a tri‐sesquiterpenoid alcohol first isolated from tobacco, and it is widely distributed in plants of the Solanaceae family. Solanesol (SNL) is an intermediate in the synthesis of coenzyme Q10 (CoQ10), an antioxidant which protects nerve cells. This study investigated the protective effect of SNL at doses of 30 and 60 mg/kg in gentamicin‐induced nephrotoxicity in Wistar albino rats. Animals were distributed into six groups and administered 100 mg/kg gentamicin‐intraperitoneal injection for 14 days. Biochemical assessments were performed on kidney homogenate, blood, and serum. Treatment with SNL was shown as lower serum levels of creatinine, blood urea nitrogen (BUN), thiobarbituric acid reactive substances (TBARS), and Tumor necrosis factor alpha)TNF‐α ((p