Symptomatic Chikungunya Virus Infection and Pregnancy Outcomes: A Nested Case-Control Study in French Guiana

During the Chikungunya epidemic in the Caribbean and Latin America, pregnant women were affected by the virus in French Guiana. The question of the impact of the virus on pregnancy was raised because of the lack of scientific consensus and published data in the region. Thus, during the Chikungunya o...

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Bibliographic Details
Published in:Viruses 2022-12, Vol.14 (12), p.2705
Main Authors: Basurko, Célia, Hcini, Najeh, Demar, Magalie, Abboud, Philippe, The CMFdeng Study Group, Nacher, Mathieu, Carles, Gabriel, Lambert, Véronique, Matheus, Séverine
Format: Article
Language:English
Subjects:
Antibodies
Case-Control Studies
Chikungunya Fever
Chikungunya virus
Complications and side effects
Dengue fever
Enzymes
Epidemics
Female
Fever
French Guiana
French Guiana - epidemiology
Genomes
Health aspects
Humans
Infant, Newborn
Infections
Intensive Care Units, Neonatal
Laboratories
Life Sciences
Microbiology and Parasitology
neonatal outcomes
Neonates
Patient outcomes
Physiological aspects
Pregnancy
Pregnancy complications
pregnancy outcomes
Pregnant women
Sociodemographics
Virology
Viruses
Womens health
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Summary:During the Chikungunya epidemic in the Caribbean and Latin America, pregnant women were affected by the virus in French Guiana. The question of the impact of the virus on pregnancy was raised because of the lack of scientific consensus and published data in the region. Thus, during the Chikungunya outbreak in French Guiana, a comparative study was set up using a cohort of pregnant women. The objective was to compare pregnancy and neonatal outcomes between pregnant women with Chikungunya virus (CHIKV) infection and pregnant women without CHIKV. Of 653 mothers included in the cohort, 246 mothers were included in the case-control study: 73 had CHIKV fever during pregnancy and 173 had neither fever nor CHIKV during pregnancy. The study did not observe any severe clinical presentation of CHIKV in the participating women. There were no intensive care unit admissions. In addition, the study showed no significant difference between the two groups with regard to pregnancy complications. However, the results showed a potential excess risk of neonatal ICU admission of the newborn when the maternal infection occurred within 7 days before delivery. These results suggest that special attention should be paid to neonates whose mothers were infected with CHIKV shortly before delivery.
ISSN:1999-4915
1999-4915
DOI:10.3390/v14122705