Is radiation-induced ovarian ablation in breast cancer an obsolete procedure? Results of a meta-analysis

A meta-analysis was conducted to assess the impact of radiation-induced ovarian ablation (RT-OA) on amenorrhea cessation rates, progression-free survival, and overall survival in pre/perimenopausal women with breast cancer. The Medline, CANCERLIT, and Cochrane Library databases and search engines we...

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Bibliographic Details
Published in:Breast cancer targets and therapy 2016-01, Vol.8 (Issue 1), p.109-116
Main Authors: Asiri, Mushabbab Al, Tunio, Mutahir A, Abdulmoniem, Reham
Format: Article
Language:English
Subjects:
Ablation
Amenorrhea
Bias
Breast cancer
Cancer therapies
Chemotherapy
Collaboration
Fertility
Leukemia
Menstruation
Meta-analysis
Metastasis
Oncology
Original Research
pre/perimenopausal
Radiation induced ovarian ablation
Radiation therapy
Software
Studies
Womens health
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Summary:A meta-analysis was conducted to assess the impact of radiation-induced ovarian ablation (RT-OA) on amenorrhea cessation rates, progression-free survival, and overall survival in pre/perimenopausal women with breast cancer. The Medline, CANCERLIT, and Cochrane Library databases and search engines were searched to identify randomized controlled studies comparing RT-OA with control for early or metastatic breast cancer. Further, radiotherapy doses, techniques, and associated side effects were evaluated. Six controlled trials with a total patient population of 3,317 were identified. Pooled results from these trials showed significant amenorrhea rates (P
ISSN:1179-1314
1179-1314
DOI:10.2147/BCTT.S94617