Consistency of spatial dynamics of HIV-1 and HCV among HIV-1/HCV coinfected drug users in China

As the transmission routes of human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV) are similar, previous studies based on separate research on HIV-1 and HCV assumed a similar transmission pattern. However, few studies have focused on the possible correlation of the spatial dynamic...

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Bibliographic Details
Published in:BMC infectious diseases 2021-09, Vol.21 (1), p.1-1001, Article 1001
Main Authors: Wang, Yu, Chen, Xin, Ye, Mei, Pang, Wei, Zhang, Chiyu, Xiong, Si-Dong, Zheng, Yong-Tang
Format: Article
Language:English
Subjects:
Blood & organ donations
Coinfection
Comorbidity
Consistency
Demographic aspects
Distribution
Drug abuse
Drug addicts
Drug users
Dynamics
Ethnicity
HCV
Health aspects
Hepatitis C
HIV
HIV infection
HIV-1
Human immunodeficiency virus
Infectious diseases
Phylogenetics
Phylogeny
Phylogeography
Polymerase chain reaction
Software
Spatial dynamic
Yunnan
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Summary:As the transmission routes of human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV) are similar, previous studies based on separate research on HIV-1 and HCV assumed a similar transmission pattern. However, few studies have focused on the possible correlation of the spatial dynamics of HIV-1 and HCV among HIV-1/HCV coinfected patients. A total of 310 HIV-1/HCV coinfected drug users were recruited in Yingjiang and Kaiyuan prefectures, Yunnan Province, China. HIV-1 env, p17, pol and HCV C/E2, NS5B fragments were amplified and sequenced from serum samples. The genetic characteristics and spatial dynamics of HIV-1 and HCV were explored by phylogenetic, bootscanning, and phylogeographic analyses. Among HIV-1/HCV coinfected drug users, eight HCV subtypes (1a, 1b, 3a, 3b, 6a, 6n, 6v, and 6u) and two HIV-1 subtypes (subtype B and subtype C), three HIV-1 circulating recombinant forms (CRF01_AE, CRF07_BC and CRF08_BC), and four unique recombinant forms (URF_BC, URF_01B, URF_01C and URF_01BC) were identified. HCV subtype 3b was the most predominant subtype in both Yingjiang and Kaiyuan prefectures. The dominant circulating HIV-1 subtypes for drug users among the two areas were CRF08_BC and URF_BC. Maximum clade credibility trees revealed that both HIV-1 and HCV were transmitted from Yingjiang to Kaiyuan. The spatial dynamics of HIV-1 and HCV among HIV-1/HCV coinfected drug users seem to have high consistency, providing theoretical evidence for the prevention of HIV-1 and HCV simultaneously.
ISSN:1471-2334
1471-2334
DOI:10.1186/s12879-021-06711-6