Exploiting 1,2,3-Triazolium Ionic Liquids for Synthesis of Tryptanthrin and Chemoselective Extraction of Copper(II) Ions and Histidine-Containing Peptides

Based on a common structural core of 4,5,6,7-tetrahydro[1,2,3]triazolo[1,5- ]pyridine, a number of bicyclic triazolium ionic liquids - were designed and successfully prepared. In our hands, this optimized synthesis of ionic liquids and requires no chromatographic separation. Also in this work, ionic...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2016-10, Vol.21 (10), p.1355-1355
Main Authors: Li, Hsin-Yi, Chen, Chien-Yuan, Cheng, Hui-Ting, Chu, Yen-Ho
Format: Article
Language:English
Subjects:
affinity ionic liquid
Air pollution
Biochemistry
Bridged Bicyclo Compounds, Heterocyclic - chemical synthesis
Bridged Bicyclo Compounds, Heterocyclic - chemistry
Chemical synthesis
chemoselective extraction
Chromatography
Communication
Copper
Copper - chemistry
copper ion
Cu-free click reaction
Histidine - chemistry
ionic liquid
Ionic Liquids - chemical synthesis
Ionic Liquids - chemistry
Molecular Structure
Natural products
peptide
Peptides
Peptides - chemistry
Peptides - isolation & purification
Quinazolines - chemical synthesis
Quinazolines - chemistry
Solvents
Triazoles - chemical synthesis
Triazoles - chemistry
tryptanthrin synthesis
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Summary:Based on a common structural core of 4,5,6,7-tetrahydro[1,2,3]triazolo[1,5- ]pyridine, a number of bicyclic triazolium ionic liquids - were designed and successfully prepared. In our hands, this optimized synthesis of ionic liquids and requires no chromatographic separation. Also in this work, ionic liquids , were shown to be efficient ionic solvents for fast synthesis of tryptanthrin natural product. Furthermore, a new affinity ionic liquid was tailor-synthesized and displayed its effectiveness in chemoselective extraction of both Cu(II) ions and, for the first time, histidine-containing peptides.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules21101355