Evaluation of salivary interleukin-6 in children with early childhood caries after treatment

Background: The role of cytokines as a marker in the oral inflammatory process in ECC has not been fully explored before and after full mouth rehabilitation. Aims: The aim of this study was to assess the level of salivary interleukin-6 (IL-6) in children with ECC and to compare its levels before and...

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Bibliographic Details
Published in:Contemporary clinical dentistry 2016-04, Vol.7 (2), p.198-202
Main Authors: Menon, Medhini, Balagopal, R, Sajitha, Krishnan, Parvathy, Kumaran, Sangeetha, G, Arun, X, Sureshkumar, Janardhanan
Format: Article
Language:English
Subjects:
Bacterial infections
Children
Children & youth
Cytokines
Dental caries
Dentistry
Down syndrome
early childhood caries
Health aspects
Hygiene
Interleukins
Mouth
Original
Patients
Pediatrics
Quality of life
Rehabilitation
Risk factors
salivary interleukin-6
Studies
Teeth
Tumor necrosis factor-TNF
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Summary:Background: The role of cytokines as a marker in the oral inflammatory process in ECC has not been fully explored before and after full mouth rehabilitation. Aims: The aim of this study was to assess the level of salivary interleukin-6 (IL-6) in children with ECC and to compare its levels before and after comprehensive full mouth rehabilitation. Methods and Materials: Saliva samples were collected from children with ECC prior to dental treatment and 3-month post treatment. The salivary IL-6 levels were analyzed using the ELISA method. The gingival index was also timely recorded. Oral health awareness sessions were conducted for children and their parents at regular intervals during the 3-month study period. Statistical analysis used: Wilcoxon Signed Rank test compared the levels of salivary IL-6 while, the paired t test compared the values of gingival index before and after treatment. Results: The mean level of salivary IL-6 before and 3 months after treatment had reduced and this reduction was statistically significant (P< 0.000). The gingival index scores had also reduced significantly 3-months post treatment (P< 0.002). Conclusions: Children with ECC when completely rehabilitated and kept under frequent follow up, which includes reinforcement of oral hygiene measures and maintaining a low caries activity state, the level of inflammation (IL-6) can definitely be minimized and thereby improving the quality of life of affected children.
ISSN:0976-237X
0976-2361
DOI:10.4103/0976-237X.183059