Dose-dependent L-dopa/carbidopa-induced hyponatremia presenting with hiccups

Levodopa (L-dopa) is the most effective antiparkinsonian agent and is well tolerated at all stages of the disease. However, both motor and nonmotor adverse events are reported with the use of L-dopa. Electrolyte imbalances such as hyponatremia and hiccups with L-dopa/carbidopa are very rare. For the...

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Bibliographic Details
Published in:Journal of family medicine and primary care 2020-03, Vol.9 (3), p.1749-1751
Main Authors: Shihabudheen, P, Anver, P, Uvais, N, Mohammed, T
Format: Article
Language:English
Subjects:
adverse events
Antiparkinson agents
Aripiprazole
Case Report
Complications and side effects
Diseases
Dosage and administration
Electrolytes
Entacapone
hiccups
Hyponatremia
L-dopa
l-dopa/carbidopa
Phenols (Class of compounds)
Pramipexole
Sulbactam
Telmisartan
Time
Tolvaptan
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Summary:Levodopa (L-dopa) is the most effective antiparkinsonian agent and is well tolerated at all stages of the disease. However, both motor and nonmotor adverse events are reported with the use of L-dopa. Electrolyte imbalances such as hyponatremia and hiccups with L-dopa/carbidopa are very rare. For the first time, we are reporting a case of L-dopa/carbidopa-induced hyponatremia and hiccup cooccurring in a 75-year-old male. He symptomatically improved after reducing the dose of levodopa/carbidopa, indicating a dose-dependent nature of these adverse events. Clinicians who prescribe L-dopa/carbidopa should be mindful of the potential for precipitating SIADH and hiccups, especially in elderly patients.
ISSN:2249-4863
2278-7135
DOI:10.4103/jfmpc.jfmpc_1044_19