Long-term myopia control effect and safety in children wearing DIMS spectacle lenses for 6 years

• Published in: Scientific reports 2023-04, Vol.13 (1), p.5475-5475, Article 5475
• Main Authors: Lam, Carly Siu Yin, Tang, Wing Chun, Zhang, Han Yu, Lee, Paul H., Tse, Dennis Yan Yin, Qi, Hua, Vlasak, Natalia, To, Chi Ho
• Format: Article
• Language: English
• Subjects: 692/308; 692/700; Child; Elongation; Eyeglasses; Humanities and Social Sciences; Humans; multidisciplinary; Myopia; Myopia - therapy; Refraction, Ocular; Science; Science (multidisciplinary); Vision Tests
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-023-32700-7

This study evaluated the long-term myopia control effect and safety in children wearing Defocus Incorporated Multiple Segments (DIMS) spectacle lenses. Participants who completed the 2-year RCT were followed for a total of 6 years; their cycloplegic refractions and axial length were measured. Group 1 (n = 36) wore DIMS spectacles for 6 years; Group 2 (n = 14) wore DIMS lens for the first 3.5 years and SV spectacles afterwards; Group 3 (n = 22) wore SV spectacles in the first 2 years and switched to DIMS; Group 4 (n = 18) wore SV spectacles in the first 2 years, switched to DIMS for 1.5 years and then SV spectacles again. Group 1 showed no significant differences in myopia progression (− 0.52 ± 0.66 vs. − 0.40 ± 0.72D) and axial elongation (0.32 ± 0.26 vs. 0.28 ± 0.28 mm, both p  > 0.05) between the first and the later 3 years. In the last 2.5 years, DIMS lens groups (Groups 1 and 3) had less myopia progression and axial elongation than the single vision groups (Groups 2 and 4). There was no evidence of rebound after stopping the treatment. Post-wear visual functions in all groups were within norms. The results supported that DIMS lenses provided sustained myopia control without adverse effects over the 6-year study period. Trial registration: clinicaltrials.gov; NCT02206217.