Development of fetal growth charts in twins stratified by chorionicity and mode of conception: a retrospective cohort study in China

Twin pregnancies continue to increase worldwide; however, the current clinical prenatal evaluation for the intrauterine growth of twins still relies on the growth standards of singletons. We attempted to establish a set of fetal biometric references for Chinese twin pregnancies, stratified by chorio...

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Published in:Chinese medical journal 2021-07, Vol.134 (15), p.1819-1827
Main Authors: Xia, Yuan-Qing, Lyu, Shu-Ping, Zhang, Jun, Chen, Yi-Ting, Gao, Li, Zhao, An-Da, Wang, Yan-Lin, Li, Sheng-Hui
Format: Article
Language:English
Subjects:
Biometrics
Birth weight
Body mass index
China
Cohort analysis
Diabetes
Female
Fetal Development
Fetuses
Gestational age
Growth Charts
Humans
Original
Pregnancy
Pregnancy complications
Pregnancy, Twin
Retrospective Studies
Standard deviation
Twins
Ultrasonic imaging
Ultrasonography, Prenatal
Womens health
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description Twin pregnancies continue to increase worldwide; however, the current clinical prenatal evaluation for the intrauterine growth of twins still relies on the growth standards of singletons. We attempted to establish a set of fetal biometric references for Chinese twin pregnancies, stratified by chorionicity and conception mode as spontaneously conceived monochorionic diamniotic (SC-MCDA), spontaneously conceived dichorionic diamniotic (SC-DCDA), and assisted reproductive technology dichorionic diamniotic (ART-DCDA) twins. From 2016 to 2019, the ultrasonographic fetal biometric measurements were longitudinally collected in pregnant women, including fetal weight, biparietal diameter, head circumference, abdominal circumference, femur length, and humerus length. The linear mixed models were used to test the difference of growth patterns between groups, and the growth curve of each biometric parameter was modeled by a generalized additive model for location scale and shape. A total of 929 twin pregnant women and 2019 singleton pregnant women, met the inclusion criteria. Among twin pregnancies, 148 were SC-MCDA, 215 were SC-DCDA, and 566 were ART-DCDA twins. Overall, SC-DCDA twins grew faster than SC-MCDA twins, while slower than ART-DCDA twins (all P 
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We attempted to establish a set of fetal biometric references for Chinese twin pregnancies, stratified by chorionicity and conception mode as spontaneously conceived monochorionic diamniotic (SC-MCDA), spontaneously conceived dichorionic diamniotic (SC-DCDA), and assisted reproductive technology dichorionic diamniotic (ART-DCDA) twins. From 2016 to 2019, the ultrasonographic fetal biometric measurements were longitudinally collected in pregnant women, including fetal weight, biparietal diameter, head circumference, abdominal circumference, femur length, and humerus length. The linear mixed models were used to test the difference of growth patterns between groups, and the growth curve of each biometric parameter was modeled by a generalized additive model for location scale and shape. A total of 929 twin pregnant women and 2019 singleton pregnant women, met the inclusion criteria. Among twin pregnancies, 148 were SC-MCDA, 215 were SC-DCDA, and 566 were ART-DCDA twins. Overall, SC-DCDA twins grew faster than SC-MCDA twins, while slower than ART-DCDA twins (all P &lt; 0.05), and all of the three groups showed significant differences comparing with singletons, especially during the third trimester. Hence, the customized fetal growth charts of each fetal biometric parameter were, respectively, constructed for SC-MCDA, SC-DCDA, and ART-DCDA twins. The fetal biometric trajectories demonstrated characteristic patterns according to chorionicity and conception mode. 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subjects Biometrics
Birth weight
Body mass index
China
Cohort analysis
Diabetes
Female
Fetal Development
Fetuses
Gestational age
Growth Charts
Humans
Original
Pregnancy
Pregnancy complications
Pregnancy, Twin
Retrospective Studies
Standard deviation
Twins
Ultrasonic imaging
Ultrasonography, Prenatal
Womens health
title Development of fetal growth charts in twins stratified by chorionicity and mode of conception: a retrospective cohort study in China
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