Effect of maternal supplementation with vitamin E on the concentration of α-tocopherol in colostrum

To evaluate the effect of maternal supplementation with vitamin E on the concentration of α-tocopherol in colostrum and its supply to the newborn. This randomized clinical trial enrolled 99 healthy adult pregnant women; of these, 39 were assigned to the control group and 60 to the supplemented group...

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Bibliographic Details
Published in:Jornal de pediatria 2017-01, Vol.93 (1), p.40-46
Main Authors: Melo, Larisse Rayanne Miranda de, Clemente, Heleni Aires, Bezerra, Dalila Fernandes, Dantas, Raquel Costa Silva, Ramalho, Héryka Myrna Maia, Dimenstein, Roberto
Format: Article
Language:English
Subjects:
Adult
Alfa-tocoferol
Alpha-tocopherol
alpha-Tocopherol - analysis
Colostro humano
Colostrum - chemistry
Dietary Supplements - analysis
Female
Human colostrum
Humans
Infant, Newborn
Lactation
Maternal Nutritional Physiological Phenomena
Maternal supplementation
Milk, Human - chemistry
Newborn
Nutritional needs
PEDIATRICS
Recém-nascido
Requerimento nutricional
Suplementação materna
Vitamin E
Vitamin E - administration & dosage
Vitamin E - analysis
Vitamina E
Vitamins - administration & dosage
Vitamins - analysis
Young Adult
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Summary:To evaluate the effect of maternal supplementation with vitamin E on the concentration of α-tocopherol in colostrum and its supply to the newborn. This randomized clinical trial enrolled 99 healthy adult pregnant women; of these, 39 were assigned to the control group and 60 to the supplemented group. After an overnight fast, 5mL of blood and 2mL of colostrum were collected. After the first sampling (0h milk), the supplemented group received 400IU of supplementary vitamin E. Another 2mL milk aliquot was collected in both groups 24h after supplementation (24h milk). The samples were analyzed by high-performance liquid chromatography. The α-tocopherol content provided by colostrum was calculated by considering a daily intake of 396mL of milk and comparing the resulting value to the recommended daily intake for infants aged 0–6 months (4mg/day). The initial mean concentration of α-tocopherol in colostrum was 1509.3±793.7μg/dL in the control group and 1452.9±808.6μg/dL in the supplemented group. After 24h, the mean α-tocopherol concentration was 1650.6±968.7μg/dL in the control group (p>0.05) and 2346.9±1203.2μg/dL in the supplemented group (p
ISSN:0021-7557
1678-4782
1678-4782
DOI:10.1016/j.jped.2016.03.007