Methodological Approaches for Risk Assessment of Tobacco and Related Products

Health risk assessment of tobacco and related products (TRPs) is highly challenging due to the variety in products, even within the product class, the complex mixture of components in the emission and the variety of user behaviour. In this paper, we summarize methods that can be used to assess the h...

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Bibliographic Details
Published in:Toxics (Basel) 2022-08, Vol.10 (9), p.491
Main Authors: Staal, Yvonne C. M, Bos, Peter M. J, Talhout, Reinskje
Format: Article
Language:English
Subjects:
Electronic cigarettes
Emission analysis
Emissions
Environmental aspects
Hazards
Health aspects
Health risk assessment
Health risks
Methods
Mixtures
Nicotine
Risk assessment
Smoking
Tobacco
Tobacco products
Topography
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Summary:Health risk assessment of tobacco and related products (TRPs) is highly challenging due to the variety in products, even within the product class, the complex mixture of components in the emission and the variety of user behaviour. In this paper, we summarize methods that can be used to assess the health risks associated with the use of TRPs. The choice of methods to be used and the data needed are dependent on the aim. Risk assessment can be used to identify the emission components of highest health concern. Alternatively, risk assessment methods can be used to determine the absolute risk of a TRP, which is the health risk of a product, not related to other products, or to determine the relative risk of a TRP, which is the health risk of a TRP compared to, for example, a cigarette. Generally, health risk assessment can be based on the effects of the complete mixture (whole smoke) or based on the (added) effects of individual components. Data requirements are dependent on the method used, but most methods require substantial data on identity and quantity of components in emissions and on the hazards of these components. Especially for hazards, only limited data are available. Currently, due to a lack of suitable data, quantitative risk assessment methods cannot be used to inform regulation.
ISSN:2305-6304
2305-6304
DOI:10.3390/toxics10090491