Formal synthesis of bastimolide A using a chiral Horner-Wittig reagent and a bifunctional aldehyde as key building blocks

The macrolide bastimolide A represents an attractive synthetic target due to its promising activity against resistant strains of the malaria pathogen plasmodium falciparum. We report a straightforward formal synthesis of bastimolide A using a Horner-Wittig reagent and an aldehyde derived from the sa...

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Published in:Tetrahedron chem 2024-03, Vol.9, p.100065, Article 100065
Main Authors: Celik, Ibrahim-Ethem, Mittendorf, Fabia, Gómez-Suárez, Adrián, Kirsch, Stefan F.
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description The macrolide bastimolide A represents an attractive synthetic target due to its promising activity against resistant strains of the malaria pathogen plasmodium falciparum. We report a straightforward formal synthesis of bastimolide A using a Horner-Wittig reagent and an aldehyde derived from the same chiral-pool based intermediate as key building blocks. [Display omitted]
doi_str_mv 10.1016/j.tchem.2024.100065
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title Formal synthesis of bastimolide A using a chiral Horner-Wittig reagent and a bifunctional aldehyde as key building blocks
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