Red ginger-extract nanoemulsion modulates high blood pressure in rats by regulating angiotensin-converting enzyme production

Red ginger (RG) has reportedly been used in folk medicine for the management and prevention of hypertension. One of the hypertension study models in experimental animals is the unilateral ureteral obstruction (UUO). This study aimed at evaluating the effect of RG-extract (RGE) nanoemulsion on UUO-in...

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Bibliographic Details
Published in:Veterinary World 2021-01, Vol.14 (1), p.176-181
Main Authors: Hanifah, Nada, Achmad, Yusuf Farid, Humaira, Aida, Salasia, Siti Isrina Oktavia
Format: Article
Language:English
Subjects:
ACE inhibitors
angiotensin-converting enzyme
Angiotensin-converting enzyme inhibitors
Animal models
Blood pressure
Chronic kidney failure
Coconut oil
Consciousness
Emulsions
Enzyme-linked immunosorbent assay
Enzymes
Ethanol
Hypertension
Kidney diseases
Measuring instruments
nanoemulsion
Nanoemulsions
Particle size
Peptidyl-dipeptidase A
Polyethylene glycol
Polyols
Production processes
red ginger
Surface active agents
unilateral ureteral obstruction
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Summary:Red ginger (RG) has reportedly been used in folk medicine for the management and prevention of hypertension. One of the hypertension study models in experimental animals is the unilateral ureteral obstruction (UUO). This study aimed at evaluating the effect of RG-extract (RGE) nanoemulsion on UUO-induced hypertension and angiotensin-converting enzyme (ACE) production in rats. RG was extracted using ethanol, combined with virgin coconut oil, polysorbate 80, and polyethylene glycol 400 to form the oil phase. The particle sizes of RGE nanoemulsions were analyzed using a particle size analyzer. The UUO method was used to induce chronic kidney disease in rats (504 mg/200 g and 360 mg/200 g b/w per oral for 7 days). The systolic and diastolic blood pressure was determined non-invasively in conscious state by tail plethysmography using an automated blood pressure monitor. ACE in serum was measured using enzyme-linked immunosorbent assay. The RGE nanoemulsions exhibited a particle size of32.8 nm and a polydispersity index (PI) of 0.268, indicating a homogenous nanoemulsion. UUO rats treated with RGE nanoemulsion (360 mg/200 g b/w) experienced a significant decrease in both their systolic blood pressure (p
ISSN:0972-8988
2231-0916
DOI:10.14202/vetworld.2021.176-181