The Prevalence and Genetic Characteristics of Porcine Circovirus Type 2 in Shandong Province, China, 2018-2020

Porcine circovirus type 2 (PCV2) is an important swine pathogen that has caused considerable economic losses in the global swine industry. During our surveillance of pigs in Shandong, China, from 2018 to 2020, we found that the PCV2 infection rate was 7.89% (86/1090). In addition, we found frequent...

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Bibliographic Details
Published in:Current issues in molecular biology 2024-11, Vol.46 (12), p.13542-13553
Main Authors: Zhao, Yuzhong, Cui, Xinyu, Sang, Haotian, Wen, Shaodong, Han, Lebin, Yang, Pingping, Xiao, Yihong, Hou, Yanmeng
Format: Article
Language:English
Subjects:
genetic diversity
infection
PCV2b
PCV2d
porcine circovirus
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Summary:Porcine circovirus type 2 (PCV2) is an important swine pathogen that has caused considerable economic losses in the global swine industry. During our surveillance of pigs in Shandong, China, from 2018 to 2020, we found that the PCV2 infection rate was 7.89% (86/1090). In addition, we found frequent mixed infections of PCV2 with porcine reproductive and respiratory syndrome virus (PRRSV), classical swine fever virus (CSFV), and porcine herpesvirus (PRV). Thirteen positive clinical samples were selected to amplify the complete genome of PCV2, and were sequenced. Among the 13, we detected two genotypes: PCV2b (1/13) and PCV2d (12/13). This suggests that PCV2d is the dominant genotype circulating in Shandong Province. Additionally, we found three positively selected sites in the ORF2 region, located on the previously reported antigenic epitopes. This investigation will contribute to understanding of the molecular epidemiology and genetic diversity of PCV2 strains in China.
ISSN:1467-3045
1467-3037
1467-3045
DOI:10.3390/cimb46120809