Comparative study of dinoprostone and misoprostol for induction of labor in patients with premature rupture of membranes after 35 weeks

The modalities of induction of labor in the event of premature rupture of membranes are controversial. The main purpose of this study was to compare the modalities of delivery after the use of dinoprostone or misoprostol for labor induction in the preterm rupture of membranes after 35 weeks in women...

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Published in:Scientific reports 2022-09, Vol.12 (1), p.14996-14996, Article 14996
Main Authors: Sire, Flavie, Ponthier, Laure, Eyraud, Jean-Luc, Catalan, Cyrille, Aubard, Yves, Coste Mazeau, Perrine
Format: Article
Language:English
Subjects:
692/308
692/700
Administration, Intravaginal
Cohort Studies
Dinoprostone - pharmacology
Female
Humanities and Social Sciences
Humans
Infant, Newborn
Labor, Induced
Misoprostol - therapeutic use
multidisciplinary
Oxytocics - pharmacology
Oxytocics - therapeutic use
Pregnancy
Pregnancy Outcome
Retrospective Studies
Science
Science (multidisciplinary)
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Summary:The modalities of induction of labor in the event of premature rupture of membranes are controversial. The main purpose of this study was to compare the modalities of delivery after the use of dinoprostone or misoprostol for labor induction in the preterm rupture of membranes after 35 weeks in women with an unfavorable cervix. We then studied maternal and fetal morbidity for the two drugs. Retrospective, single-center, comparative cohort study in a level 3 maternity unit in France from 2009 to 2018 comparing vaginal administration of misoprostol 50 µg every six hours (maximum 150 µg) and administration of dinoprostone 10 mg, a slow-release vaginal insert, for 24 h (maximum 20 mg), for labor induction in the preterm rupture of membranes after 35 weeks in women with an unfavorable cervix (Bishop score 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-022-18948-5