Prenylated Flavonoids of the Moraceae Family: A Comprehensive Review of Their Biological Activities

Prenylated flavonoids (PFs) are natural flavonoids with a prenylated side chain attached to the flavonoid skeleton. They have great potential for biological activities such as anti-diabetic, anti-cancer, antimicrobial, antioxidant, anti-inflammatory, enzyme inhibition, and anti-Alzheimer's effe...

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Published in:Plants (Basel) 2024-05, Vol.13 (9), p.1211
Main Authors: Morante-Carriel, Jaime, Živković, Suzana, Nájera, Hugo, Sellés-Marchart, Susana, Martínez-Márquez, Ascensión, Martínez-Esteso, María José, Obrebska, Anna, Samper-Herrero, Antonio, Bru-Martínez, Roque
Format: Article
Language:English
Subjects:
Antidiabetics
bioactivities
Bioflavonoids
Biosynthesis
Design optimization
Diabetes
Diabetes mellitus
Enzyme kinetics
Flavones
Flavonoids
Glycoproteins
Health aspects
Inflammation
Kinases
Metabolism
Metabolites
Moraceae
Moraceae family
Pharmacology
Pharmacology, Experimental
Polyphenols
prenylated compounds
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Summary:Prenylated flavonoids (PFs) are natural flavonoids with a prenylated side chain attached to the flavonoid skeleton. They have great potential for biological activities such as anti-diabetic, anti-cancer, antimicrobial, antioxidant, anti-inflammatory, enzyme inhibition, and anti-Alzheimer's effects. Medicinal chemists have recently paid increasing attention to PFs, which have become vital for developing new therapeutic agents. PFs have quickly developed through isolation and semi- or full synthesis, proving their high value in medicinal chemistry research. This review comprehensively summarizes the research progress of PFs, including natural PFs from the Moraceae family and their pharmacological activities. This information provides a basis for the selective design and optimization of multifunctional PF derivatives to treat multifactorial diseases.
ISSN:2223-7747
2223-7747
DOI:10.3390/plants13091211