4D‐Flow MRI intracardiac flow analysis considering different subtypes of pulmonary hypertension

Intracardiac flow hemodynamic patterns have been considered to be an early sign of diastolic dysfunction. In this study we investigated right ventricular (RV) diastolic dysfunction between patients with pulmonary arterial hypertension (PAH) and pulmonary hypertension with chronic lung disease (PH‐CL...

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Bibliographic Details
Published in:Pulmonary circulation 2023-10, Vol.13 (4), p.e12307-n/a
Main Authors: Cain, Michael T., Schäfer, Michal, Ross, Lexie K., Ivy, David D., Mitchell, Max B., Fenster, Brett E., Bull, Todd M., Barker, Alex J., Vargas, Daniel, Hoffman, Jordan R. H.
Format: Article
Language:English
Subjects:
4D‐Flow MRI
diastolic dysfunction
Pulmonary hypertension
right ventricle
vorticity
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Summary:Intracardiac flow hemodynamic patterns have been considered to be an early sign of diastolic dysfunction. In this study we investigated right ventricular (RV) diastolic dysfunction between patients with pulmonary arterial hypertension (PAH) and pulmonary hypertension with chronic lung disease (PH‐CLD) via 4D‐Flow cardiac MRI (CMR). Patients underwent prospective, comprehensive CMR for function and size including 4D‐Flow CMR protocol for intracardiac flow visualization and analysis. RV early filling phase and peak atrial phase vorticity (E‐vorticity and A‐vorticity) values were calculated in all patients. Patients further underwent comprehensive Doppler and tissue Doppler evaluation for the RV diastolic dysfunction. In total 13 patients with PAH, 15 patients with PH‐CLD, and 10 control subjects underwent the 4D‐Flow CMR and echocardiography evaluation for RV diastolic dysfunction. Reduced E‐vorticity differentiated PAH and PH‐CLD from healthy controls (both p 
ISSN:2045-8940
2045-8932
2045-8940
DOI:10.1002/pul2.12307