Exosomal miRNAs and miRNA dysregulation in cancer-associated fibroblasts

The present review aimed to assess the role of exosomal miRNAs in cancer-associated fibroblasts (CAFs), normal fibroblasts (NFs), and cancer cells. The roles of exosomal miRNAs and miRNA dysregulation in CAF formation and activation were summarized. All relevant publications were retrieved from the...

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Bibliographic Details
Published in:Molecular cancer 2017-08, Vol.16 (1), p.148-148, Article 148
Main Authors: Yang, Fengming, Ning, Zhiqiang, Ma, Ling, Liu, Weitao, Shao, Chuchu, Shu, Yongqian, Shen, Hua
Format: Article
Language:English
Subjects:
Animals
Cancer
Cancer-Associated Fibroblasts
Development and progression
Exosome
Exosomes
Fibroblasts
Gene Expression Regulation, Neoplastic
Genetic aspects
Humans
Mechanism
Metastasis
Mice
MicroRNA
MicroRNAs
MiRNA
Physiological aspects
Review
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Summary:The present review aimed to assess the role of exosomal miRNAs in cancer-associated fibroblasts (CAFs), normal fibroblasts (NFs), and cancer cells. The roles of exosomal miRNAs and miRNA dysregulation in CAF formation and activation were summarized. All relevant publications were retrieved from the PubMed database, with key words such as CAFs, CAF, stromal fibroblasts, cancer-associated fibroblasts, miRNA, exosomal, exosome, and similar terms. Recent studies have revealed that CAFs, NFs, and cancer cells can secrete exosomal miRNAs to affect each other. Dysregulation of miRNAs and exosomal miRNAs influence the formation and activation of CAFs. Furthermore, miRNA dysregulation in CAFs is considered to be associated with a secretory phenotype change, tumor invasion, tumor migration and metastasis, drug resistance, and poor prognosis. Finding of exosomal miRNA secretion provides novel insights into communication among CAFs, NFs, and cancer cells. MicroRNA dysregulation is also involved in the whole processes of CAF formation and function. Dysregulation of miRNAs in CAFs can affect the secretory phenotype of the latter cells.
ISSN:1476-4598
1476-4598
DOI:10.1186/s12943-017-0718-4