Miniaturizable ion-selective arrays based on highly stable polymer membranes for biomedical applications

Poly(vinylchloride) (PVC) is the most common polymer matrix used in the fabrication of ion-selective electrodes (ISEs). However, the surfaces of PVC-based sensors have been reported to show membrane instability. In an attempt to overcome this limitation, here we developed two alternative methods for...

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Bibliographic Details
Published in:Sensors (Basel, Switzerland) Switzerland), 2014-07, Vol.14 (7), p.11844-11854
Main Authors: Mir, Mònica, Lugo, Roberto, Tahirbegi, Islam Bogachan, Samitier, Josep
Format: Article
Language:English
Subjects:
Arrays
Biocompatibility
Biocompatible Materials - chemistry
biomedicine
Bridged Bicyclo Compounds, Heterocyclic - chemistry
Cirurgia endoscòpica
Electrochemistry
Electrodes
Electrodes, Implanted
Electroquímica
Elèctrodes selectius d'ions
endoscope
Endoscopic surgery
Equipment Design
Equipment Failure Analysis
implantable device
Ion selective electrodes
ion-selective electrode (ISE) sensor
Ischemia
Isquèmia
Materials Testing
Membranes
Membranes, Artificial
Microarray Analysis - instrumentation
Miniaturization
pH detection
Platforms
Polyethylene Glycols - chemistry
Polymerization
Polymers
Polymers - chemistry
Polyvinyl chlorides
Reproducibility
Sensors
Stability
Toxicity
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Summary:Poly(vinylchloride) (PVC) is the most common polymer matrix used in the fabrication of ion-selective electrodes (ISEs). However, the surfaces of PVC-based sensors have been reported to show membrane instability. In an attempt to overcome this limitation, here we developed two alternative methods for the preparation of highly stable and robust ion-selective sensors. These platforms are based on the selective electropolymerization of poly(3,4-ethylenedioxythiophene) (PEDOT), where the sulfur atoms contained in the polymer covalently interact with the gold electrode, also permitting controlled selective attachment on a miniaturized electrode in an array format. This platform sensor was improved with the crosslinking of the membrane compounds with poly(ethyleneglycol) diglycidyl ether (PEG), thus also increasing the biocompatibility of the sensor. The resulting ISE membranes showed faster signal stabilization of the sensor response compared with that of the PVC matrix and also better reproducibility and stability, thus making these platforms highly suitable candidates for the manufacture of robust implantable sensors.
ISSN:1424-8220
1424-8220
DOI:10.3390/s140711844