Comparison of amyloid PET measured in Centiloid units with neuropathological findings in Alzheimer's disease

The Centiloid scale was developed to standardise the results of beta-amyloid (Aβ) PET. We aimed to determine the Centiloid unit (CL) thresholds for CERAD sparse and moderate-density neuritic plaques, Alzheimer's disease neuropathologic change (ADNC) score of intermediate or high probability of...

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Bibliographic Details
Published in:Alzheimer's research & therapy 2020-03, Vol.12 (1), p.22-22, Article 22
Main Authors: Amadoru, Sanka, Doré, Vincent, McLean, Catriona A, Hinton, Fairlie, Shepherd, Claire E, Halliday, Glenda M, Leyton, Cristian E, Yates, Paul A, Hodges, John R, Masters, Colin L, Villemagne, Victor L, Rowe, Christopher C
Format: Article
Language:English
Subjects:
Advertising executives
Aged
Alzheimer Disease - diagnosis
Alzheimer Disease - pathology
Alzheimer's disease
Amyloid beta-Peptides - analysis
Amyloid beta-protein
Amyloid imaging
Biomarkers
Brain - pathology
Brain research
Centiloids
Dementia
Development and progression
Diagnosis
Diagnostic imaging
Diseases
Female
Florbetapir
Flutemetamol
Health aspects
Humans
Male
Measurement
Medical research
Neuropathology
Plaque, Amyloid - diagnosis
Plaque, Amyloid - pathology
Positron emission tomography
Positron-Emission Tomography - methods
Radiopharmaceuticals
Software
Telecommunications equipment
Time
Tomography
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Summary:The Centiloid scale was developed to standardise the results of beta-amyloid (Aβ) PET. We aimed to determine the Centiloid unit (CL) thresholds for CERAD sparse and moderate-density neuritic plaques, Alzheimer's disease neuropathologic change (ADNC) score of intermediate or high probability of Alzheimer's Disease (AD), final clinicopathological diagnosis of AD, and expert visual read of a positive Aβ PET scan. Aβ PET results in CL for 49 subjects were compared with post-mortem findings, visual read, and final clinicopathological diagnosis. The Youden Index was used to determine the optimal CL thresholds from receiver operator characteristic (ROC) curves. A threshold of 20.1 CL (21.3 CL when corrected for time to death, AUC 0.97) yielded highest accuracy in detecting moderate or frequent plaque density while  45 CL. Positive visual read agreed highly with results > 26 CL. Centiloid values  20 CL indicated the presence of at least moderate plaque density, but approximately 50 CL or more best confirmed both neuropathological and clinicopathological diagnosis of Alzheimer's disease.
ISSN:1758-9193
1758-9193
DOI:10.1186/s13195-020-00587-5