Small dense low density lipoprotein-cholesterol and cholesterol ratios to predict arterial stiffness progression in normotensive subjects over a 5-year period

Small dense low density lipoprotein-cholesterol (sdLDL-C), cholesterol ratios and carotid-femoral pulse wave velocity (cf-PWV) impart risk for all-cause morbidity and mortality independently of conventional cardiovascular disease (CVD) risk factors. This study was designed to identify feasible indic...

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Bibliographic Details
Published in:Lipids in health and disease 2018-02, Vol.17 (1), p.27-27, Article 27
Main Authors: Li, Gang, Wu, Hui-Kun, Wu, Xiao-Wei, Cao, Zhe, Tu, Yuan-Chao, Ma, Yi, Wang, Wei-Qing, Cheng, Jian, Zhou, Zi-Hua
Format: Article
Language:English
Subjects:
Adult
Analysis
Arterial stiffness
Cardiovascular diseases
Cardiovascular Diseases - blood
Cardiovascular Diseases - physiopathology
Carotid Arteries - physiopathology
Cholesterol - blood
Cholesterol ratios
Cholesterol, HDL - blood
Cholesterol, LDL
Cholesterol, LDL - blood
Development and progression
Female
Health aspects
Humans
Hypertension
Male
Middle Aged
Mortality
Normotensive
Pulse Wave Analysis
Risk Factors
sdLDL-C
Triglycerides - blood
Vascular Stiffness
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Summary:Small dense low density lipoprotein-cholesterol (sdLDL-C), cholesterol ratios and carotid-femoral pulse wave velocity (cf-PWV) impart risk for all-cause morbidity and mortality independently of conventional cardiovascular disease (CVD) risk factors. This study was designed to identify feasible indicators for predicting arterial stiffness progression. We followed up 816 normotensive participants without diabetes or CVD for nearly 5.0 years. Cholesterol parameters, ratios and other clinical and laboratory data were collected at baseline. cf-PWV were measured at baseline and the end of follow-up. PWV progression subjects had higher levels of PWV parameters, sdLDL-C and TG/HDL-C ratio. sdLDL-C and TG/HDL-C were significantly correlated with all PWV parameters. Multiple regression models showed that sdLDL-C was closely associated with follow-up PWV (β = 0.222, p 
ISSN:1476-511X
1476-511X
DOI:10.1186/s12944-018-0671-2