Serum Hepcidin-25 and All-Cause Mortality in Patients Undergoing Maintenance Hemodialysis

Hepcidin plays an important role in iron homeostasis, inhibits intestinal iron absorption and iron release from hepatocytes and macrophages, while its clinical utility remained unclear. This study aimed to investigate the associations between hepcidin-25 and mortality in MHD patients. This was a pro...

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Bibliographic Details
Published in:International journal of general medicine 2021-01, Vol.14, p.3153-3162
Main Authors: Zou, Lu-Xi, Sun, Ling, Hua, Rui-Xue, Wu, Yu
Format: Article
Language:English
Subjects:
Albumin
Analysis
Anemia
Binding sites
Blood pressure
China
Chronic kidney failure
Creatinine
Datasets
Enzymes
esrd
Ferritin
Hemodialysis
Hemoglobin
hepcidin
Hypoxia
Iron
Kidney diseases
Kidney transplants
Laboratories
Medical research
Medicine, Experimental
Mortality
Original Research
Patient outcomes
survival analysis
Variables
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Summary:Hepcidin plays an important role in iron homeostasis, inhibits intestinal iron absorption and iron release from hepatocytes and macrophages, while its clinical utility remained unclear. This study aimed to investigate the associations between hepcidin-25 and mortality in MHD patients. This was a prospective observational cohort of 161 MHD patients, with 2-year follow-up. We investigated the relationships between the variables in our dataset, including serum hepcidin-25, demographic characteristics as well as other clinical parameters. The median value of baseline serum hepcidin-25 was 31.0 (12.1, 57.3) ng/mL; therefore, the patients were stratified into two groups (low-level hepcidin-25 group, and high-level hepcidin-25 group). The serum iron, serum ferritin, transferrin saturation (TSAT), and hsCRP were higher, pre-dialysis creatinine and albumin were lower, and the scores of health-related qualities of life were worse in the high-level hepcidin-25 group than in the low-level hepcidin-25 group. Maximal information-based nonparametric exploration analysis suggested that serum hepcidin-25 was associated with ferritin, TSAT, and all-cause mortality. The patients with hepcidin-25
ISSN:1178-7074
1178-7074
DOI:10.2147/IJGM.S313777