Investigating genetic overlaps of the genetic factor differentiating schizophrenia from bipolar disorder with cognitive function and hippocampal volume

Schizophrenia and bipolar disorder display clinical similarities and dissimilarities. We investigated whether the genetic factor differentiating schizophrenia from bipolar disorder is genetically associated with cognitive phenotypes and hippocampal volumes. We revealed genetic overlaps of the geneti...

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Bibliographic Details
Published in:BJPsych open 2022-01, Vol.8 (1), p.e33, Article e33
Main Authors: Ohi, Kazutaka, Muto, Yukimasa, Takai, Kentaro, Sugiyama, Shunsuke, Shioiri, Toshiki
Format: Article
Language:English
Subjects:
Academic Psychiatry
Autism
Bipolar disorder
Brain research
Cognitive ability
cognitive function
Consortia
Educational attainment
Gene loci
Genetic correlation
Genomes
hippocampus
Intelligence
Mental disorders
Schizophrenia
Short Report
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Summary:Schizophrenia and bipolar disorder display clinical similarities and dissimilarities. We investigated whether the genetic factor differentiating schizophrenia from bipolar disorder is genetically associated with cognitive phenotypes and hippocampal volumes. We revealed genetic overlaps of the genetic differentiating factor with low general cognitive ability, low childhood IQ, low educational attainment and reduced hippocampal volumes. The genetic correlations with low general cognitive ability and reduced hippocampal volumes were associated with risk of schizophrenia, whereas the genetic correlations with high childhood IQ and educational attainment were associated with risks of bipolar disorder. These findings suggest these disorders have disorder-specific genetic factors related to clinical phenotypes.
ISSN:2056-4724
2056-4724
DOI:10.1192/bjo.2021.1086