CircGPC3 promotes hepatocellular carcinoma progression and metastasis by sponging miR-578 and regulating RAB7A/PSME3 expression

CircRNAs are a class of highly stable noncoding RNAs that play an important role in the progression of many diseases, especially cancer. In this study, high-throughput sequencing was used to screen for abnormally expressed circRNAs, and we found that circGPC3 was overexpressed in HCC tissues. Howeve...

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Bibliographic Details
Published in:Scientific reports 2024-04, Vol.14 (1), p.7632-7632, Article 7632
Main Authors: Ju, Linling, Luo, Yunfeng, Cui, Xiaohui, Zhang, Hao, Chen, Lin, Yao, Min
Format: Article
Language:English
Subjects:
631/337/384
631/67/395
631/80
Apoptosis
Cell migration
Circular RNA
Hepatocellular carcinoma
Humanities and Social Sciences
Liver cancer
Lymph nodes
Metastases
multidisciplinary
Next-generation sequencing
Science
Science (multidisciplinary)
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Summary:CircRNAs are a class of highly stable noncoding RNAs that play an important role in the progression of many diseases, especially cancer. In this study, high-throughput sequencing was used to screen for abnormally expressed circRNAs, and we found that circGPC3 was overexpressed in HCC tissues. However, the underlying mechanism of circGPC3 in the development and metastasis of hepatocellular carcinoma (HCC) remains unknown. In our study, we found that circGPC3 was significantly upregulated in HCC tissues and cells and that its overexpression was positively correlated with overall survival, TNM stage and lymph node metastasis. In vivo and in vitro experiments showed that circGPC3 knockdown repressed HCC cell migration, invasion and proliferation and promoted apoptosis. Mechanistically, circGPC3 promoted HCC proliferation and metastasis through the miR-578/RAB7A/PSME3 axis. Our results demonstrate that circGPC3 contributes to the progression of HCC and provides an intervention target for HCC.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-024-58004-y