Early Evolution of Transcription Systems and Divergence of Archaea and Bacteria

DNA template-dependent multi-subunit RNA polymerases (RNAPs) found in all three domains of life and some viruses are of the two-double-Ψ-β-barrel (DPBB) type. The 2-DPBB protein format is also found in some RNA template-dependent RNAPs and a major replicative DNA template-dependent DNA polymerase (D...

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Bibliographic Details
Published in:Frontiers in molecular biosciences 2021-05, Vol.8, p.651134-651134
Main Authors: Lei, Lei, Burton, Zachary F.
Format: Article
Language:English
Subjects:
archaea
bacteria
double-Ψ-β-barrel
general transcription factor evolution
Molecular Biosciences
promoter evolution
transcription
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Summary:DNA template-dependent multi-subunit RNA polymerases (RNAPs) found in all three domains of life and some viruses are of the two-double-Ψ-β-barrel (DPBB) type. The 2-DPBB protein format is also found in some RNA template-dependent RNAPs and a major replicative DNA template-dependent DNA polymerase (DNAP) from Archaea (PolD). The 2−DPBB family of RNAPs and DNAPs probably evolved prior to the last universal common cellular ancestor (LUCA). Archaeal Transcription Factor B (TFB) and bacterial σ factors include homologous strings of helix-turn-helix units. The consequences of TFB-σ homology are discussed in terms of the evolution of archaeal and bacterial core promoters. Domain-specific DPBB loop inserts functionally connect general transcription factors to the RNAP active site. Archaea appear to be more similar to LUCA than Bacteria. Evolution of bacterial σ factors from TFB appears to have driven divergence of Bacteria from Archaea, splitting the prokaryotic domains.
ISSN:2296-889X
2296-889X
DOI:10.3389/fmolb.2021.651134