Combined Estrogen Alpha and Beta Receptor Expression Has a Prognostic Significance for Colorectal Cancer Patients

We reported that high estrogen receptor beta (ERβ) expression is independently associated with better prognosis in female colorectal cancer (CRC) patients. However, estrogen receptor alpha (ERα) is expressed at very low levels in normal colon mucosa, and its prognostic role in CRC has not been explo...

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Bibliographic Details
Published in:Frontiers in medicine 2022-03, Vol.9, p.739620-739620
Main Authors: Topi, Geriolda, Ghatak, Souvik, Satapathy, Shakti Ranjan, Ehrnström, Roy, Lydrup, Marie-Louise, Sjölander, Anita
Format: Article
Language:English
Subjects:
Cancer and Oncology
Cancer och onkologi
Clinical Medicine
colorectal cancer
CRC disease-free survival
CRC overall survival
estrogen receptor alpha
estrogen receptor beta
Klinisk medicin
Medical and Health Sciences
Medicin och hälsovetenskap
Medicine
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Summary:We reported that high estrogen receptor beta (ERβ) expression is independently associated with better prognosis in female colorectal cancer (CRC) patients. However, estrogen receptor alpha (ERα) is expressed at very low levels in normal colon mucosa, and its prognostic role in CRC has not been explored. Herein, we investigated the combined role of ERα and ERβ expression in the prognosis of female patients with CRC, which, to the best of our knowledge, is the first study to investigate this topic. A total number of 306 primary CRCs were immunostained for ERα and ERβ expression. A Cox regression model was used to evaluate overall survival (OS) and disease-free survival (DFS). The combined expression of high ERβ + negative ERα correlates with longer OS (HR = 0.23; 95% CI: 0.11-0.45,
ISSN:2296-858X
2296-858X
DOI:10.3389/fmed.2022.739620