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Combined Estrogen Alpha and Beta Receptor Expression Has a Prognostic Significance for Colorectal Cancer Patients
We reported that high estrogen receptor beta (ERβ) expression is independently associated with better prognosis in female colorectal cancer (CRC) patients. However, estrogen receptor alpha (ERα) is expressed at very low levels in normal colon mucosa, and its prognostic role in CRC has not been explo...
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| Published in: | Frontiers in medicine 2022-03, Vol.9, p.739620-739620 |
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| creator | Topi, Geriolda Ghatak, Souvik Satapathy, Shakti Ranjan Ehrnström, Roy Lydrup, Marie-Louise Sjölander, Anita |
| description | We reported that high estrogen receptor beta (ERβ) expression is independently associated with better prognosis in female colorectal cancer (CRC) patients. However, estrogen receptor alpha (ERα) is expressed at very low levels in normal colon mucosa, and its prognostic role in CRC has not been explored. Herein, we investigated the combined role of ERα and ERβ expression in the prognosis of female patients with CRC, which, to the best of our knowledge, is the first study to investigate this topic. A total number of 306 primary CRCs were immunostained for ERα and ERβ expression. A Cox regression model was used to evaluate overall survival (OS) and disease-free survival (DFS). The combined expression of high ERβ + negative ERα correlates with longer OS (HR = 0.23; 95% CI: 0.11-0.45, |
| doi_str_mv | 10.3389/fmed.2022.739620 |
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| fullrecord | <record><control><sourceid>proquest_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_cc57e3759c6b4ea1b26b6a33b0285576</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_cc57e3759c6b4ea1b26b6a33b0285576</doaj_id><sourcerecordid>2646718742</sourcerecordid><originalsourceid>FETCH-LOGICAL-c531t-d0d106afe748e9969af5fe81675c39b66294919f844aaaa41d4dd496019c9963</originalsourceid><addsrcrecordid>eNpVkk1vEzEQhlcIRKvSOyfkI5cEf3t9QSpRoJUiUUEP3KxZ7zh1tVlv7Q0f_x6HlKq1NLJlv34843mb5i2jSyFa-yHssF9yyvnSCKs5fdGccm71olXtj5dP1ifNeSl3lFImuJJMvG5OhBKaGtaeNvertOviiD1ZlzmnLY7kYphugcDYk084A_mGHqc5ZbL-PWUsJaaRXEIhQK6rfkxljp58j9sxhuhh9EhCFa_SkDL6GQayOmxmcg1zxHEub5pXAYaC5w_zWXPzeX2zulxsvn65Wl1sFl4JNi962jOqIaCRLVqrLQQVsGXaKC9spzW30jIbWimhDsl62ffSasqsr3Jx1lwdsX2COzfluIP8xyWI7t9GylsHuaY-oPNeGRRGWa87icA6rjsNQnSUt0qZA2tzZJVfOO27Z7RhP9XoariCrgfDQxuoo8Z4J23grlNWOs4o2C6EWpSsuI9HXGXVHvr6KxmGZ9TnJ2O8ddv007W1LqtYBbx_AOR0v8cyu10sHocBRkz74riWunbXSF6l9Cj1OZWSMTw-w6g72MgdbOQONnJHG9Ur756m93jhv2nEX4EvxNs</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2646718742</pqid></control><display><type>article</type><title>Combined Estrogen Alpha and Beta Receptor Expression Has a Prognostic Significance for Colorectal Cancer Patients</title><source>PubMed Central</source><creator>Topi, Geriolda ; Ghatak, Souvik ; Satapathy, Shakti Ranjan ; Ehrnström, Roy ; Lydrup, Marie-Louise ; Sjölander, Anita</creator><creatorcontrib>Topi, Geriolda ; Ghatak, Souvik ; Satapathy, Shakti Ranjan ; Ehrnström, Roy ; Lydrup, Marie-Louise ; Sjölander, Anita</creatorcontrib><description>We reported that high estrogen receptor beta (ERβ) expression is independently associated with better prognosis in female colorectal cancer (CRC) patients. However, estrogen receptor alpha (ERα) is expressed at very low levels in normal colon mucosa, and its prognostic role in CRC has not been explored. Herein, we investigated the combined role of ERα and ERβ expression in the prognosis of female patients with CRC, which, to the best of our knowledge, is the first study to investigate this topic. A total number of 306 primary CRCs were immunostained for ERα and ERβ expression. A Cox regression model was used to evaluate overall survival (OS) and disease-free survival (DFS). The combined expression of high ERβ + negative ERα correlates with longer OS (HR = 0.23; 95% CI: 0.11-0.45,
<0.0001) and DFS (HR = 0.10; 95% CI: 0.03-0.26,
< 0.0001) and a more favorable tumor outcome, as well as significantly higher expression of antitumorigenic proteins than combined expression of low ERβ + positive ERα. Importantly, we found that low ERβ expression was associated with local recurrence of CRC, whereas ERα expression was correlated with liver metastasis. Overall, our results show that the combined high ERβ + negative ERα expression correlated with a better prognosis for CRC patients. Our results suggest that the combined expression of ERα and ERβ could be used as a predictive combination marker for CRC patients, especially for predicting DFS.</description><identifier>ISSN: 2296-858X</identifier><identifier>EISSN: 2296-858X</identifier><identifier>DOI: 10.3389/fmed.2022.739620</identifier><identifier>PMID: 35360718</identifier><language>eng</language><publisher>Switzerland: Frontiers Media S.A</publisher><subject>Cancer and Oncology ; Cancer och onkologi ; Clinical Medicine ; colorectal cancer ; CRC disease-free survival ; CRC overall survival ; estrogen receptor alpha ; estrogen receptor beta ; Klinisk medicin ; Medical and Health Sciences ; Medicin och hälsovetenskap ; Medicine</subject><ispartof>Frontiers in medicine, 2022-03, Vol.9, p.739620-739620</ispartof><rights>Copyright © 2022 Topi, Ghatak, Satapathy, Ehrnström, Lydrup and Sjölander.</rights><rights>Copyright © 2022 Topi, Ghatak, Satapathy, Ehrnström, Lydrup and Sjölander. 2022 Topi, Ghatak, Satapathy, Ehrnström, Lydrup and Sjölander</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c531t-d0d106afe748e9969af5fe81675c39b66294919f844aaaa41d4dd496019c9963</citedby><cites>FETCH-LOGICAL-c531t-d0d106afe748e9969af5fe81675c39b66294919f844aaaa41d4dd496019c9963</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8963951/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8963951/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35360718$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://lup.lub.lu.se/record/da72f8f0-077c-49f2-b594-210a9bff0d14$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Topi, Geriolda</creatorcontrib><creatorcontrib>Ghatak, Souvik</creatorcontrib><creatorcontrib>Satapathy, Shakti Ranjan</creatorcontrib><creatorcontrib>Ehrnström, Roy</creatorcontrib><creatorcontrib>Lydrup, Marie-Louise</creatorcontrib><creatorcontrib>Sjölander, Anita</creatorcontrib><title>Combined Estrogen Alpha and Beta Receptor Expression Has a Prognostic Significance for Colorectal Cancer Patients</title><title>Frontiers in medicine</title><addtitle>Front Med (Lausanne)</addtitle><description>We reported that high estrogen receptor beta (ERβ) expression is independently associated with better prognosis in female colorectal cancer (CRC) patients. However, estrogen receptor alpha (ERα) is expressed at very low levels in normal colon mucosa, and its prognostic role in CRC has not been explored. Herein, we investigated the combined role of ERα and ERβ expression in the prognosis of female patients with CRC, which, to the best of our knowledge, is the first study to investigate this topic. A total number of 306 primary CRCs were immunostained for ERα and ERβ expression. A Cox regression model was used to evaluate overall survival (OS) and disease-free survival (DFS). The combined expression of high ERβ + negative ERα correlates with longer OS (HR = 0.23; 95% CI: 0.11-0.45,
<0.0001) and DFS (HR = 0.10; 95% CI: 0.03-0.26,
< 0.0001) and a more favorable tumor outcome, as well as significantly higher expression of antitumorigenic proteins than combined expression of low ERβ + positive ERα. Importantly, we found that low ERβ expression was associated with local recurrence of CRC, whereas ERα expression was correlated with liver metastasis. Overall, our results show that the combined high ERβ + negative ERα expression correlated with a better prognosis for CRC patients. Our results suggest that the combined expression of ERα and ERβ could be used as a predictive combination marker for CRC patients, especially for predicting DFS.</description><subject>Cancer and Oncology</subject><subject>Cancer och onkologi</subject><subject>Clinical Medicine</subject><subject>colorectal cancer</subject><subject>CRC disease-free survival</subject><subject>CRC overall survival</subject><subject>estrogen receptor alpha</subject><subject>estrogen receptor beta</subject><subject>Klinisk medicin</subject><subject>Medical and Health Sciences</subject><subject>Medicin och hälsovetenskap</subject><subject>Medicine</subject><issn>2296-858X</issn><issn>2296-858X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNpVkk1vEzEQhlcIRKvSOyfkI5cEf3t9QSpRoJUiUUEP3KxZ7zh1tVlv7Q0f_x6HlKq1NLJlv34843mb5i2jSyFa-yHssF9yyvnSCKs5fdGccm71olXtj5dP1ifNeSl3lFImuJJMvG5OhBKaGtaeNvertOviiD1ZlzmnLY7kYphugcDYk084A_mGHqc5ZbL-PWUsJaaRXEIhQK6rfkxljp58j9sxhuhh9EhCFa_SkDL6GQayOmxmcg1zxHEub5pXAYaC5w_zWXPzeX2zulxsvn65Wl1sFl4JNi962jOqIaCRLVqrLQQVsGXaKC9spzW30jIbWimhDsl62ffSasqsr3Jx1lwdsX2COzfluIP8xyWI7t9GylsHuaY-oPNeGRRGWa87icA6rjsNQnSUt0qZA2tzZJVfOO27Z7RhP9XoariCrgfDQxuoo8Z4J23grlNWOs4o2C6EWpSsuI9HXGXVHvr6KxmGZ9TnJ2O8ddv007W1LqtYBbx_AOR0v8cyu10sHocBRkz74riWunbXSF6l9Cj1OZWSMTw-w6g72MgdbOQONnJHG9Ur756m93jhv2nEX4EvxNs</recordid><startdate>20220314</startdate><enddate>20220314</enddate><creator>Topi, Geriolda</creator><creator>Ghatak, Souvik</creator><creator>Satapathy, Shakti Ranjan</creator><creator>Ehrnström, Roy</creator><creator>Lydrup, Marie-Louise</creator><creator>Sjölander, Anita</creator><general>Frontiers Media S.A</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>ADTPV</scope><scope>AGCHP</scope><scope>AOWAS</scope><scope>D8T</scope><scope>D95</scope><scope>ZZAVC</scope><scope>DOA</scope></search><sort><creationdate>20220314</creationdate><title>Combined Estrogen Alpha and Beta Receptor Expression Has a Prognostic Significance for Colorectal Cancer Patients</title><author>Topi, Geriolda ; Ghatak, Souvik ; Satapathy, Shakti Ranjan ; Ehrnström, Roy ; Lydrup, Marie-Louise ; Sjölander, Anita</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c531t-d0d106afe748e9969af5fe81675c39b66294919f844aaaa41d4dd496019c9963</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Cancer and Oncology</topic><topic>Cancer och onkologi</topic><topic>Clinical Medicine</topic><topic>colorectal cancer</topic><topic>CRC disease-free survival</topic><topic>CRC overall survival</topic><topic>estrogen receptor alpha</topic><topic>estrogen receptor beta</topic><topic>Klinisk medicin</topic><topic>Medical and Health Sciences</topic><topic>Medicin och hälsovetenskap</topic><topic>Medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Topi, Geriolda</creatorcontrib><creatorcontrib>Ghatak, Souvik</creatorcontrib><creatorcontrib>Satapathy, Shakti Ranjan</creatorcontrib><creatorcontrib>Ehrnström, Roy</creatorcontrib><creatorcontrib>Lydrup, Marie-Louise</creatorcontrib><creatorcontrib>Sjölander, Anita</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SwePub</collection><collection>SWEPUB Lunds universitet full text</collection><collection>SwePub Articles</collection><collection>SWEPUB Freely available online</collection><collection>SWEPUB Lunds universitet</collection><collection>SwePub Articles full text</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Frontiers in medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Topi, Geriolda</au><au>Ghatak, Souvik</au><au>Satapathy, Shakti Ranjan</au><au>Ehrnström, Roy</au><au>Lydrup, Marie-Louise</au><au>Sjölander, Anita</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Combined Estrogen Alpha and Beta Receptor Expression Has a Prognostic Significance for Colorectal Cancer Patients</atitle><jtitle>Frontiers in medicine</jtitle><addtitle>Front Med (Lausanne)</addtitle><date>2022-03-14</date><risdate>2022</risdate><volume>9</volume><spage>739620</spage><epage>739620</epage><pages>739620-739620</pages><issn>2296-858X</issn><eissn>2296-858X</eissn><abstract>We reported that high estrogen receptor beta (ERβ) expression is independently associated with better prognosis in female colorectal cancer (CRC) patients. However, estrogen receptor alpha (ERα) is expressed at very low levels in normal colon mucosa, and its prognostic role in CRC has not been explored. Herein, we investigated the combined role of ERα and ERβ expression in the prognosis of female patients with CRC, which, to the best of our knowledge, is the first study to investigate this topic. A total number of 306 primary CRCs were immunostained for ERα and ERβ expression. A Cox regression model was used to evaluate overall survival (OS) and disease-free survival (DFS). The combined expression of high ERβ + negative ERα correlates with longer OS (HR = 0.23; 95% CI: 0.11-0.45,
<0.0001) and DFS (HR = 0.10; 95% CI: 0.03-0.26,
< 0.0001) and a more favorable tumor outcome, as well as significantly higher expression of antitumorigenic proteins than combined expression of low ERβ + positive ERα. Importantly, we found that low ERβ expression was associated with local recurrence of CRC, whereas ERα expression was correlated with liver metastasis. Overall, our results show that the combined high ERβ + negative ERα expression correlated with a better prognosis for CRC patients. Our results suggest that the combined expression of ERα and ERβ could be used as a predictive combination marker for CRC patients, especially for predicting DFS.</abstract><cop>Switzerland</cop><pub>Frontiers Media S.A</pub><pmid>35360718</pmid><doi>10.3389/fmed.2022.739620</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Cancer and Oncology Cancer och onkologi Clinical Medicine colorectal cancer CRC disease-free survival CRC overall survival estrogen receptor alpha estrogen receptor beta Klinisk medicin Medical and Health Sciences Medicin och hälsovetenskap Medicine |
| title | Combined Estrogen Alpha and Beta Receptor Expression Has a Prognostic Significance for Colorectal Cancer Patients |
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