Lipid accumulation product (LAP) index for the diagnosis of nonalcoholic fatty liver disease (NAFLD): a systematic review and meta-analysis

Lipid accumulation product (LAP) is an index calculated by waist circumference (WC) and triglyceride (TG), which reflects lipid toxicity. This study aims to investigate the association between the LAP index and nonalcoholic fatty liver disease (NAFLD) in a systematic review and meta-analysis. PubMed...

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Published in:Lipids in health and disease 2023-03, Vol.22 (1), p.41-13, Article 41
Main Authors: Ebrahimi, Menooa, Seyedi, Seyed Arsalan, Nabipoorashrafi, Seyed Ali, Rabizadeh, Soghra, Sarzaeim, Mojdeh, Yadegar, Amirhossein, Mohammadi, Fatemeh, Bahri, Razman Arabzadeh, Pakravan, Peyman, Shafiekhani, Paria, Nakhjavani, Manouchehr, Esteghamati, Alireza
Format: Article
Language:English
Subjects:
Age
Biopsy
Body Mass Index
Case-Control Studies
Cross-Sectional Studies
Fatty liver
Females
Humans
Insulin resistance
Lipid Accumulation Product
Lipid accumulation product (LAP)
Liver cancer
Liver cirrhosis
Liver disease (NAFLD)
Liver diseases
Magnetic resonance imaging
Meta-analysis
Metabolic syndrome
Non-alcoholic Fatty Liver Disease - complications
Non-alcoholic Fatty Liver Disease - diagnosis
Nonalcoholic fatty liver disease
Observational Studies as Topic
Review
Systematic review
Toxicity
Ultrasonic imaging
Weight control
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Summary:Lipid accumulation product (LAP) is an index calculated by waist circumference (WC) and triglyceride (TG), which reflects lipid toxicity. This study aims to investigate the association between the LAP index and nonalcoholic fatty liver disease (NAFLD) in a systematic review and meta-analysis. PubMed, Scopus, and Web of Science online databases were searched for eligible studies that investigated the association of the LAP index and NAFLD. Sixteen observational studies with 96,101 participants, including four cohort studies, one case‒control study and 11 cross-sectional studies with baseline data, were entered into this analysis. Fourteen studies reported a significant association between the LAP index and NAFLD, and two reported that this relation was not significant; two different meta-analyses (1- mean difference (MD) and 2- bivariate diagnostic test accuracy [DTA]) were conducted using Stata version 14. The LAP index was compared in subjects with and without NAFLD, and the difference was significant with 34.90 units (CI 95: 30.59-39.31, P 
ISSN:1476-511X
1476-511X
DOI:10.1186/s12944-023-01802-6