Megakaryocytes in Bone Metastasis: Protection or Progression?

Bone is the primary site where some cancers develop secondary growth, particularly those derived from breast and prostate tissue. The spread of metastasis to distant sites relies on complex mechanisms by which only cells endowed with certain characteristics are able to reach secondary growth sites....

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Bibliographic Details
Published in:Cells (Basel, Switzerland) Switzerland), 2019-02, Vol.8 (2), p.134
Main Author: Maroni, Paola
Format: Article
Language:English
Subjects:
Animals
Blood platelets
Blood Platelets - metabolism
Bone marrow
bone metastasis
Bone Neoplasms - pathology
Bone Neoplasms - prevention & control
Bone Neoplasms - secondary
Bone sialoprotein
Breast
Collagen
Disease Progression
Extracellular matrix
Extracellular Matrix - metabolism
Homeostasis
Humans
Megakaryocytes
Megakaryocytes - pathology
Metastases
Metastasis
microenvironment
Natural killer cells
Osteocalcin
Osteonectin
Osteopontin
Osteoprotegerin
Physiology
Platelets
Polyploidy
Prostate
Proteins
Review
Transcription factors
Tumors
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Summary:Bone is the primary site where some cancers develop secondary growth, particularly those derived from breast and prostate tissue. The spread of metastasis to distant sites relies on complex mechanisms by which only cells endowed with certain characteristics are able to reach secondary growth sites. Platelets play a pivotal role in tumour growth, by conferring resistance to shear stress to the circulating tumour cells and protection against natural killer cell attack. Mature polyploid megakaryocytes (MKs) reside in close proximity to the vascular sinusoids of bone marrow, where their primary function is to produce platelets. Emerging evidence has demonstrated that MKs are essential for skeletal homeostasis, due to the expression and production of the bone-related proteins osteocalcin, osteonectin, bone morphogenetic protein, osteopontin, bone sialoprotein, and osteoprotegerin. Debate surrounds the role that MKs play in the development of bone metastasis, which is the topic of this mini-review.
ISSN:2073-4409
2073-4409
DOI:10.3390/cells8020134