Synthesis, Structural Investigations, and In Vitro/In Silico Bioactivities of Flavonoid Substituted Biguanide: A Novel Schiff Base and Its Diorganotin (IV) Complexes

Quercetin is one of the most powerful bioactive dietary flavonoids. The in vivo biological study of quercetin is extremely difficult due to its very low solubility. However, diorganotin complexes of quercetin are more useful when contrasted with quercetin due to increased solubility. In the present...

Full description

Saved in:
Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2022-12, Vol.27 (24), p.8874
Main Authors: Abbas, Zahoor, Kumar, Manoj, Tuli, Hardeep Singh, Janahi, Essam M, Haque, Shafiul, Harakeh, Steve, Dhama, Kuldeep, Aggarwal, Pallvi, Varol, Mehmet, Rani, Anita, Sharma, Shashi
Format: Article
Language:English
Subjects:
Anti-infective agents
Antiinfectives and antibacterials
Antimicrobial agents
Aromatic compounds
Bacteria
biological activities
Biological activity
Biological effects
Cancer
Carbon
Chemical properties
Chemotherapy
Computer applications
Coordination Complexes
Dichlorides
diorganotin derivatives
Enzymes
Flavonoids
Flavonoids - pharmacology
Gram-Negative Bacteria
Gram-Positive Bacteria
Hypoglycemic agents
Imines
In vivo methods and tests
Kinases
Ligands
Molecular docking
Molecular Docking Simulation
Pharmaceutical research
Quercetin
Quercetin - pharmacology
Schiff base
Schiff bases
Schiff Bases - chemistry
Schiff Bases - pharmacology
Solubility
Structure
Substitutes
Tin
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Quercetin is one of the most powerful bioactive dietary flavonoids. The in vivo biological study of quercetin is extremely difficult due to its very low solubility. However, diorganotin complexes of quercetin are more useful when contrasted with quercetin due to increased solubility. In the present study, quercetin, substituted biguanide synthesized in the form of Schiff base and its di-alkyl/aryl tin (IV) complexes were obtained by condensing Schiff base with respective di-alkyl/aryl tin (IV) dichloride. Advanced analytical techniques were used for structural elucidation. The results of biological screening against Gram-positive/Gram-negative bacteria and fungi showed that these diorganotin (IV) derivatives act as potent antimicrobial agents. The in silico investigation with dihydropteroate (DHPS) disclosed a large ligand-receptor interaction and revealed a strong relationship between the natural exercises and computational molecular docking results.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules27248874