Decreased serum betatrophin may correlate with the improvement of obstructive sleep apnea after Roux-en-Y Gastric Bypass surgery

Obesity is strongly correlated with obstructive sleep apnea (OSA), and bariatric surgery can effectively treat obesity and alleviate OSA. However, the contributing factors are still unclear. We aimed to explore the relationship between betatrophin and OSA in patients undergoing Roux-en-Y gastric byp...

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Bibliographic Details
Published in:Scientific reports 2021-01, Vol.11 (1), p.1808-1808, Article 1808
Main Authors: Song, Zhiyuan, Guo, Kaifeng, Huang, Weijun, Xu, Huajun, Liu, Yupu, Guan, Jian, Yin, Shankai, Yu, Haoyong, Yi, Hongliang, Zou, Jianyin
Format: Article
Language:English
Subjects:
692/163
692/499
Apnea
Diabetes mellitus (non-insulin dependent)
Gastric bypass
Gastrointestinal surgery
Humanities and Social Sciences
Magnetic resonance imaging
multidisciplinary
Obesity
Risk factors
Science
Science (multidisciplinary)
Sleep
Sleep apnea
Sleep disorders
Surgery
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Summary:Obesity is strongly correlated with obstructive sleep apnea (OSA), and bariatric surgery can effectively treat obesity and alleviate OSA. However, the contributing factors are still unclear. We aimed to explore the relationship between betatrophin and OSA in patients undergoing Roux-en-Y gastric bypass (RYGB) surgery. Our study consisted of thirty-seven individuals with OSA and type 2 diabetes (16 males, 21 females) undergoing RYGB surgery. The polysomnography test, anthropometric results, serum betatrophin, and abdominal magnetic resonance images were evaluated both before and 1 year after RYGB surgery. Factors that may correlate with the alleviation of OSA were investigated. In our study, RYGB surgery significantly decreased apnea hypopnea index (AHI) and serum betatrophin concentration ( p  
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-021-81379-1