Anaphylaxis

Anaphylaxis is an acute, potentially fatal systemic allergic reaction with varied mechanisms and clinical presentations. Although prompt recognition and treatment of anaphylaxis are imperative, both patients and healthcare professionals often fail to recognize and diagnose early signs and symptoms o...

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Bibliographic Details
Published in:Allergy, asthma, and clinical immunology asthma, and clinical immunology, 2018-09, Vol.14 (Suppl 2), p.54-54, Article 54
Main Authors: Fischer, David, Vander Leek, Timothy K, Ellis, Anne K, Kim, Harold
Format: Article
Language:English
Subjects:
Acute management
Anaphylaxis
Anaphylaxis action plan
Diagnosis
Epinephrine
Health aspects
Long-term management
Review
Risk factors
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Summary:Anaphylaxis is an acute, potentially fatal systemic allergic reaction with varied mechanisms and clinical presentations. Although prompt recognition and treatment of anaphylaxis are imperative, both patients and healthcare professionals often fail to recognize and diagnose early signs and symptoms of the condition. Clinical manifestations vary widely; however, the most common signs are cutaneous symptoms, including urticaria, angioedema, erythema and pruritus. Immediate intramuscular administration of epinephrine into the anterolateral thigh is first-line therapy, even if the diagnosis is uncertain. The mainstays of long-term management include specialist assessment, avoidance measures, and the provision of an epinephrine auto-injector and an individualized anaphylaxis action plan. This article provides an overview of the causes, clinical features, diagnosis and acute and long-term management of this serious allergic reaction.
ISSN:1710-1484
1710-1492
1710-1492
DOI:10.1186/s13223-018-0283-4