Novel Adociaquinone Derivatives from the Indonesian Sponge Xestospongia sp

Seven new adociaquinone derivatives, xestoadociaquinones A (1a), B (1b), 14-carboxy-xestoquinol sulfate (2) and xestoadociaminals A-D (3a, 3c, 4a, 4c), together with seven known compounds (5-11) were isolated from an Indonesian marine sponge Xestospongia sp. Their structures were elucidated by exten...

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Bibliographic Details
Published in:Marine drugs 2015-04, Vol.13 (5), p.2617-2628
Main Authors: He, Fei, Mai, Linh H, Longeon, Arlette, Copp, Brent R, Loaëc, Nadège, Bescond, Amandine, Meijer, Laurent, Bourguet-Kondracki, Marie-Lise
Format: Article
Language:English
Subjects:
14-carboxy-xestoquinol sulfate
adociaquinone
Animals
Anti-Bacterial Agents - chemistry
Antioxidants - chemistry
Bacteria - drug effects
Cell Proliferation - drug effects
kinase inhibitor
Magnetic Resonance Spectroscopy - methods
Naphthoquinones - chemistry
Naphthoquinones - pharmacology
Porifera - chemistry
Protein Kinases - chemistry
xestoadociaminal
xestoadociaquinone
Xestospongia
Xestospongia - chemistry
Xestospongia sp
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Summary:Seven new adociaquinone derivatives, xestoadociaquinones A (1a), B (1b), 14-carboxy-xestoquinol sulfate (2) and xestoadociaminals A-D (3a, 3c, 4a, 4c), together with seven known compounds (5-11) were isolated from an Indonesian marine sponge Xestospongia sp. Their structures were elucidated by extensive 1D and 2D NMR and mass spectrometric data. All the compounds were evaluated for their potential inhibitory activity against eight different protein kinases involved in cell proliferation, cancer, diabetes and neurodegenerative disorders as well as for their antioxidant and antibacterial activities.
ISSN:1660-3397
1660-3397
DOI:10.3390/md13052617