Association Between the Gut Microbiota and Blood Pressure in a Population Cohort of 6953 Individuals

Background Several small-scale animal studies have suggested that gut microbiota and blood pressure (BP) are linked. However, results from human studies remain scarce and conflicting. We wanted to elucidate the multivariable-adjusted association between gut metagenome and BP in a large, representati...

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Published in:Journal of the American Heart Association 2020-08, Vol.9 (15), p.e016641-e016641
Main Authors: Palmu, Joonatan, Salosensaari, Aaro, Havulinna, Aki S, Cheng, Susan, Inouye, Michael, Jain, Mohit, Salido, Rodolfo A, Sanders, Karenina, Brennan, Caitriona, Humphrey, Gregory C, Sanders, Jon G, Vartiainen, Erkki, Laatikainen, Tiina, Jousilahti, Pekka, Salomaa, Veikko, Knight, Rob, Lahti, Leo, Niiranen, Teemu J
Format: Article
Language:English
Subjects:
Adult
Aged
Blood Pressure
Cohort Studies
Female
Gastrointestinal Microbiome
gastrointestinal microbiota
Humans
hypertension
Hypertension - microbiology
Lactobacillus
Male
Metagenome
Middle Aged
Original Research
salt intake
Sodium, Dietary - urine
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Summary:Background Several small-scale animal studies have suggested that gut microbiota and blood pressure (BP) are linked. However, results from human studies remain scarce and conflicting. We wanted to elucidate the multivariable-adjusted association between gut metagenome and BP in a large, representative, well-phenotyped population sample. We performed a focused analysis to examine the previously reported inverse associations between sodium intake and abundance and between abundance and BP. Methods and Results We studied a population sample of 6953 Finns aged 25 to 74 years (mean age, 49.2±12.9 years; 54.9% women). The participants underwent a health examination, which included BP measurement, stool collection, and 24-hour urine sampling (N=829). Gut microbiota was analyzed using shallow shotgun metagenome sequencing. In age- and sex-adjusted models, the α (within-sample) and β (between-sample) diversities of taxonomic composition were strongly related to BP indexes (
ISSN:2047-9980
2047-9980
DOI:10.1161/jaha.120.016641