Vitamin D and gastrointestinal diseases: inflammatory bowel disease and colorectal cancer

Over the past 5 years, there has been a rapid resurgence of interest in vitamin D outside of its traditional role in metabolic bone disease. Some nontraditional roles ascribed to vitamin D include anti-inflammatory and immune-modulating effects. These effects have led to possible implications in the...

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Published in:Therapeutic Advances in Gastroenterology 2011-01, Vol.4 (1), p.49-62
Main Authors: Raman, Maitreyi, Milestone, Andrew N., Walters, Julian R.F., Hart, Ailsa L., Ghosh, Subrata
Format: Article
Language:English
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Summary:Over the past 5 years, there has been a rapid resurgence of interest in vitamin D outside of its traditional role in metabolic bone disease. Some nontraditional roles ascribed to vitamin D include anti-inflammatory and immune-modulating effects. These effects have led to possible implications in the pathophysiology of immune-mediated diseases including multiple sclerosis and inflammatory bowel disease (IBD). In addition, vitamin D insufficiency has been linked to higher rates of cancers including colon, prostate and breast cancers. Given these diverse associations of vitamin D and disease states, this review describes recent advances with regard to vitamin D and gastrointestinal diseases, in particular IBD and colorectal cancer.
ISSN:1756-283X
1756-2848
1756-2848
DOI:10.1177/1756283X10377820