Anti-synthetase syndrome: a rare and challenging diagnosis for bilateral ground-glass opacities-a case report with literature review

Anti-synthetase syndrome (ASS) is an uncommon immune-mediated entity characterized by myositis, interstitial lung disease (ILD), non-erosive arthritis, and less common features such as fever, Raynaud's phenomenon, and skin changes in association with anti-aminoacyl-transfer-RNA antibodies, most...

Full description

Saved in:
Bibliographic Details
Published in:BMC pulmonary medicine 2021-01, Vol.21 (1), p.11-11, Article 11
Main Authors: Alfraji, Nasam, Mazahir, Usman, Chaudhri, Moiuz, Miskoff, Jeffrey
Format: Article
Language:English
Subjects:
Aminoacyl-tRNA synthetases
Anti-synthetase syndrome
Antibodies
Arthritis
Autoantibodies - immunology
Autoimmune disease
Autoimmune diseases
Case Report
Case studies
Comorbidity
Complications and side effects
Coronaviruses
Corticosteroids
COVID-19
COVID-19 - epidemiology
Diagnosis
Diagnosis, Differential
Dyspnea
Female
Fever
Health aspects
Humans
Immunomodulation
Immunosuppressive agents
Interstitial lung disease
Literature reviews
Lung - diagnostic imaging
Lung diseases
Middle Aged
Mortality
Myositis
Myositis - diagnosis
Myositis - epidemiology
Myositis - immunology
Pain
Pandemics
Patients
Pneumonia
Prognosis
Pulmonology
Rare Diseases
Ribonucleic acid
RNA
SARS-CoV-2
Serology
Tomography
Transfer RNA
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Anti-synthetase syndrome (ASS) is an uncommon immune-mediated entity characterized by myositis, interstitial lung disease (ILD), non-erosive arthritis, and less common features such as fever, Raynaud's phenomenon, and skin changes in association with anti-aminoacyl-transfer-RNA antibodies, most commonly anti-Jo-1 antibodies. We present a challenging and rare case of ASS-associated ILD presenting with unexplained respiratory symptoms and bilateral infiltrates on chest imaging during the COVID-19 pandemic. High clinical suspicion for ASS with early appropriate therapy with corticosteroids and immunosuppressive agents led to marked clinical improvement. High index of suspicion for ASS is mandated in patients with unexplained ILD. A comprehensive autoimmune work-up is important as an early treatment with corticosteroids with or without immunomodulators improves patient outcomes and survival in an otherwise poor prognostic disease.
ISSN:1471-2466
1471-2466
DOI:10.1186/s12890-020-01388-0