The Influence of Modernization and Disease on the Gastric Microbiome of Orang Asli, Myanmars and Modern Malaysians

The present study explored the differences in gastric microbiome between three distinct populations of Southeast Asia. These include the isolated Orang Asli population and modern Malaysians, as well as patients from Myanmar, the least developed country in the region. All 79 subjects recruited in thi...

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Bibliographic Details
Published in:Microorganisms (Basel) 2019-06, Vol.7 (6), p.174
Main Authors: Chua, Eng Guan, Loke, Mun Fai, Gunaletchumy, Selva Perumal, Gan, Han Ming, Thevakumar, Kavitha, Tay, Chin Yen, Young, Sylvia, Aye, Than Than, Maw, Win Win, Aye, Mya Mya, Leow, Alex Hwong-Ruey, Azmi, Ahmad Najib, Kalimuthu, Sri Ganesh, Dahlan, Haji Mohd Akmal Bin Dato, Goh, Khean Lee, Vadivelu, Jamuna
Format: Article
Language:English
Subjects:
16S rRNA gene sequencing
beta diversity
Biopsy
Developing countries
Disease
Drinking water
Dyspepsia
Endoscopy
Ethics
Gastric cancer
gastric disease
Gastritis
Helicobacter pylori
Infections
LDCs
Malaysian
microbiome
Microbiomes
Microbiota
Microorganisms
Modernization
Myanmar
Orang Asli
Populations
Sanitation
Species diversity
Species richness
Statistical analysis
Taxonomy
Water supply
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Summary:The present study explored the differences in gastric microbiome between three distinct populations of Southeast Asia. These include the isolated Orang Asli population and modern Malaysians, as well as patients from Myanmar, the least developed country in the region. All 79 subjects recruited in this study had infection. Based on alpha diversity analysis, Orang Asli had the richest and most diverse gastric microbiome, followed by Myanmar and modern Malaysian groups. Beta diversity analysis revealed significant separation of samples between different populations. These observations are likely to be associated with the level of modernization of each population. Our data further suggested increased bacterial species richness and diversity of the gastric microbiome in individuals who were less modernized, particularly in the Orang Asli group, could suppress the growth of . In addition, there were significant variations in the gastric microbiome between modern Malaysians with different types of gastric diseases. Notably, was present at significantly greater abundance level in patients with non-ulcerative dyspepsia than those with peptic-ulcer diagnosis. This suggests that may also play a role in gastritis besides , which merits further investigation.
ISSN:2076-2607
2076-2607
DOI:10.3390/microorganisms7060174