Vitamin D as a marker of cognitive decline in elderly Indian population

Very few studies in India have addressed the role of vitamin D in cognitive function. The present study was conducted to assess the serum levels of 25-hydroxyvitamin D (25(OH)D) and its association with markers of cognitive impairment and homocysteine levels in the elderly Indian population. The stu...

Full description

Saved in:
Bibliographic Details
Published in:Annals of the Indian Academy of Neurology 2015-07, Vol.18 (3), p.314-319
Main Authors: Vedak, Tejal Kanhaiya, Ganwir, Vaishali, Shah, Arun B, Pinto, Charles, Lele, Vikram R, Subramanyam, Alka, Shah, Hina, Deo, Sudha Shrikant
Format: Article
Language:English
Subjects:
Alzheimer's disease
Biological markers
Cognitive decline
Cognitive disorders
Dementia
Diagnosis
Health aspects
Health risk assessment
homocysteine
Identification and classification
MMSE score
Original
Statistics
Vitamin D
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Very few studies in India have addressed the role of vitamin D in cognitive function. The present study was conducted to assess the serum levels of 25-hydroxyvitamin D (25(OH)D) and its association with markers of cognitive impairment and homocysteine levels in the elderly Indian population. The study population consisted of patients with dementia (Group A, n = 32), mild cognitive impairment (MCI; Group B, n = 24), and elderly age-matched controls (Group C, n = 30). Measurement of serum levels of 25(OH)D and total homocysteine were done. Significant decreased concentration of 25(OH)D and increased concentration of homocysteine was observed. Association of serum levels of vitamin D with markers of cognitive decline as well as serum homocysteine levels was observed in patients with dementia and MCI when compared to controls. Correlation of vitamin D with markers of cognitive decline and homocysteine opens a new door for early diagnosis of cognitive impairment.
ISSN:0972-2327
1998-3549
DOI:10.4103/0972-2327.160052