Metabolite Profiling and Dipeptidyl Peptidase IV Inhibitory Activity of Coreopsis Cultivars in Different Mutations

Coreopsis species have been developed to produce cultivars of various floral colors and sizes and are also used in traditional medicine. To identify and evaluate mutant cultivars of C. rosea and C. verticillata, their phytochemical profiles were systematically characterized using ultra-performance l...

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Bibliographic Details
Published in:Plants (Basel) 2021-08, Vol.10 (8), p.1661
Main Authors: Kim, Bo-Ram, Paudel, Sunil Babu, Han, Ah-Reum, Park, Jisu, Kil, Yun-Seo, Choi, Hyukjae, Jeon, Yeo Gyeong, Park, Kong Young, Kang, Si-Yong, Jin, Chang Hyun, Kim, Jin-Baek, Nam, Joo-Won
Format: Article
Language:English
Subjects:
Acids
Coreopsis
Coreopsis rosea
Coreopsis verticillata
Cultivars
Diabetes
Diabetes mellitus
Dietary supplements
Dipeptidyl-peptidase IV
Discriminant analysis
Flavonoids
Glucose
Liquid chromatography
Mass spectrometry
Mass spectroscopy
Metabolites
metabolomics
mutant cultivar
Mutation
Peptidase
Peptidases
Phytochemicals
Principal components analysis
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Summary:Coreopsis species have been developed to produce cultivars of various floral colors and sizes and are also used in traditional medicine. To identify and evaluate mutant cultivars of C. rosea and C. verticillata, their phytochemical profiles were systematically characterized using ultra-performance liquid chromatography time-of-flight mass spectrometry, and their anti-diabetic effects were evaluated using the dipeptidyl peptidase (DPP)-IV inhibitor screening assay. Forty compounds were tentatively identified. This study is the first to provide comprehensive chemical information on the anti-diabetic effect of C. rosea and C. verticillata. All 32 methanol extracts of Coreopsis cultivars inhibited DPP-IV activity in a concentration-dependent manner (IC50 values: 34.01–158.83 μg/mL). Thirteen compounds presented as potential markers for distinction among the 32 Coreopsis cultivars via principal component analysis and orthogonal partial least squares discriminant analysis. Therefore, these bio-chemometric models can be useful in distinguishing cultivars as potential dietary supplements for functional plants.
ISSN:2223-7747
2223-7747
DOI:10.3390/plants10081661