Comparison of serum and bronchoalveolar lavage fluid sialic acid levels between malignant and benign lung diseases

It is known that tissue and serum sialic acid levels may be altered by malignant transformation. In this study, sialic acid levels were determined in bronchoalveolar lavage fluid (BAL) and serum in two groups of patients with lung cancer and non-malignant diseases of the lung. Colorimetric methods w...

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Bibliographic Details
Published in:BMC pulmonary medicine 2001-12, Vol.1 (1), p.4-4, Article 4
Main Authors: Isitmangil, T, Isitmangil, G, Budak, Y, Aydilek, R, Celenk, M K
Format: Article
Language:English
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Summary:It is known that tissue and serum sialic acid levels may be altered by malignant transformation. In this study, sialic acid levels were determined in bronchoalveolar lavage fluid (BAL) and serum in two groups of patients with lung cancer and non-malignant diseases of the lung. Colorimetric methods were used for determination sialic acid in serum and in BAL samples. Flexible bronchoscopy was used to obtain the latter. Sialic acid levels in bronchoalveolar lavage fluid and serum did not show any statistically significant difference between subjects with malignant and the non-malignant lung diseases (p > 0.05). Sialic acid levels were also unrelated to the stage and localization of the tumor (p > 0.05). Sialic acid levels do not appear to be a good marker for discriminating malignant from non-malignant diseases of the lung.
ISSN:1471-2466
1471-2466
DOI:10.1186/1471-2466-1-4