Acute effect of passive cycle-ergometry and functional electrical stimulation on nitrosative stress and inflammatory cytokines in mechanically ventilated critically ill patients: a randomized controlled trial

• Published in: Brazilian journal of medical and biological research 2020-01, Vol.53 (4), p.e8770-e8770
• Main Authors: França, E E T, Gomes, J P V, De Lira, J M B, Amaral, T C N, Vilaça, A F, Paiva Júnior, M D S, Elihimas Júnior, U F, Correia Júnior, M A V, Forgiarini Júnior, L A, Costa, M J C, Andrade, M A, Ribeiro, L C, De Castro, C M M B
• Format: Article
• Language: English
• Subjects: Adult; Aged; Analysis; Biological response modifiers; BIOLOGY; Biomarkers - blood; Clinical trials; Critical Illness - rehabilitation; Critical Illness - therapy; Cytokines; Cytokines - blood; Cytometry; Electric properties; Electric Stimulation - methods; Electrical stimuli; Ergometry; Female; Health aspects; Humans; Inflammation; Inflammation - immunology; Inflammation - metabolism; Intensive care; Intensive care unit; Intensive Care Units; Interferon; Interferon gamma; Interleukins; Male; MEDICINE, RESEARCH & EXPERIMENTAL; Middle Aged; Motion Therapy, Continuous Passive - methods; Muscle weakness; Necrosis; Nitric oxide; Nitrogen oxides; Nitrosative stress; Nitrosative Stress - physiology; Oxidative Stress - physiology; Patients; Physical therapy; Physiotherapy; Product development; Quadriceps muscle; Quadriceps Muscle - physiopathology; Respiration, Artificial - methods; Serum levels; Stress (Psychology); Tumor necrosis factor-TNF; Tumor necrosis factor-α; Tumors
• ISSN: 0100-879X; 1414-431X; 1414-431X; 1678-4510
• DOI: 10.1590/1414-431X20208770

Early mobilization is beneficial for critically ill patients because it reduces muscle weakness acquired in intensive care units. The objective of this study was to assess the effect of functional electrical stimulation (FES) and passive cycle ergometry (PCE) on the nitrous stress and inflammatory cytometry in critically ill patients. This was a controlled, randomized, open clinical trial carried out in a 16-bed intensive care unit. The patients were randomized into four groups: Control group (n=10), did not undergo any therapeutic intervention during the study; PCE group (n=9), lower-limb PCE for 30 cycles/min for 20 min; FES group (n=9), electrical stimulation of quadriceps muscle for 20 min; and FES with PCE group (n=7), patients underwent PCE and FES, with their order determined randomly. The serum levels of nitric oxide, tumor necrosis factor alpha, interferon gamma, and interleukins 6 and 10 were analyzed before and after the intervention. There were no differences in clinical or demographic characteristics between the groups. The results revealed reduced nitric oxide concentrations one hour after using PCE (P